Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 373075..373634 Replicon chromosome
Accession NZ_CP053817
Organism Vibrio cholerae strain SA7G

Toxin (Protein)


Gene name relE Uniprot ID D7HHK2
Locus tag HPY17_RS15310 Protein ID WP_000578471.1
Coordinates 373075..373353 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag HPY17_RS15315 Protein ID WP_000381183.1
Coordinates 373350..373634 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY17_RS15260 368738..368827 + 90 WP_141239104.1 DUF645 family protein -
HPY17_RS15265 368827..368919 + 93 Protein_344 DUF645 family protein -
HPY17_RS15270 369116..369745 + 630 WP_052259807.1 hypothetical protein -
HPY17_RS15275 370218..370328 + 111 WP_084980740.1 DUF3265 domain-containing protein -
HPY17_RS15280 370365..370697 + 333 WP_138041757.1 YggL family protein -
HPY17_RS15285 370835..371377 + 543 WP_142738652.1 yfeABCD locus regulator -
HPY17_RS15290 371687..371866 + 180 Protein_349 DUF645 family protein -
HPY17_RS15295 372045..372218 + 174 WP_175247781.1 hypothetical protein -
HPY17_RS15300 372446..372517 + 72 WP_170320369.1 hypothetical protein -
HPY17_RS15305 372638..372874 + 237 WP_175247186.1 DUF645 family protein -
HPY17_RS15310 373075..373353 - 279 WP_000578471.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HPY17_RS15315 373350..373634 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HPY17_RS15320 373991..374077 + 87 WP_134820423.1 DUF645 family protein -
HPY17_RS15325 374077..374169 + 93 Protein_356 DUF645 family protein -
HPY17_RS15330 374436..374726 + 291 WP_175247656.1 YkgJ family cysteine cluster protein -
HPY17_RS15335 374902..375258 + 357 WP_175247657.1 hypothetical protein -
HPY17_RS15340 375435..375806 + 372 WP_001008376.1 hypothetical protein -
HPY17_RS15345 375978..376778 + 801 WP_002045689.1 PhzF family phenazine biosynthesis protein -
HPY17_RS15350 377035..377211 + 177 WP_175247605.1 hypothetical protein -
HPY17_RS15355 377251..378171 - 921 WP_175247658.1 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 310054..510566 200512
- inside Integron - - 311218..510566 199348
- flank IS/Tn - - 377251..378171 920


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10838.56 Da        Isoelectric Point: 4.6794

>T158035 WP_000578471.1 NZ_CP053817:c373353-373075 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T158035 NZ_CP069549:2127908-2128126 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT158035 WP_000381183.1 NZ_CP053817:c373634-373350 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT158035 NZ_CP069549:2127508-2127882 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References