Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 364622..365162 Replicon chromosome
Accession NZ_CP053817
Organism Vibrio cholerae strain SA7G

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag HPY17_RS15225 Protein ID WP_000277238.1
Coordinates 364622..364891 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag HPY17_RS15230 Protein ID WP_001258569.1
Coordinates 364884..365162 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY17_RS15180 360339..361250 + 912 WP_175247652.1 hypothetical protein -
HPY17_RS15185 361262..361432 + 171 WP_175247653.1 hypothetical protein -
HPY17_RS15190 361651..361932 + 282 WP_175247654.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HPY17_RS15195 361929..362216 + 288 WP_175247655.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY17_RS15200 362374..362838 + 465 WP_076025888.1 ASCH domain-containing protein -
HPY17_RS15205 362903..362986 + 84 Protein_332 disulfide bond formation protein DsbD -
HPY17_RS15210 362984..363400 + 417 WP_069730442.1 DUF1311 domain-containing protein -
HPY17_RS15215 363718..363936 + 219 Protein_334 DUF645 family protein -
HPY17_RS15220 364132..364368 - 237 WP_000772130.1 RNA-binding protein -
HPY17_RS15225 364622..364891 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
HPY17_RS15230 364884..365162 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HPY17_RS15235 365916..366656 + 741 WP_162813548.1 PhzF family phenazine biosynthesis protein -
HPY17_RS15240 366840..367253 + 414 WP_175246413.1 VOC family protein -
HPY17_RS15245 367321..367434 + 114 WP_081018724.1 acetyltransferase -
HPY17_RS15250 367383..367664 + 282 WP_001894429.1 DUF1289 domain-containing protein -
HPY17_RS15255 368004..368429 + 426 WP_001915043.1 hypothetical protein -
HPY17_RS15260 368738..368827 + 90 WP_141239104.1 DUF645 family protein -
HPY17_RS15265 368827..368919 + 93 Protein_344 DUF645 family protein -
HPY17_RS15270 369116..369745 + 630 WP_052259807.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 310054..510566 200512
- inside Integron - - 311218..510566 199348


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T158034 WP_000277238.1 NZ_CP053817:c364891-364622 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T158034 NZ_CP069549:c2098786-2098484 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATTGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT158034 WP_001258569.1 NZ_CP053817:c365162-364884 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT158034 NZ_CP069549:c2098448-2098107 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References