Detailed information of TA system TA158033

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 361651..362216
• Replicon: chromosome
• Accession: NZ_CP053817
• Organism: Vibrio cholerae strain SA7G

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HPY17_RS15195
• Protein ID: WP_175247655.1
• Coordinates: 361929..362216 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HPY17_RS15190
• Protein ID: WP_175247654.1
• Coordinates: 361651..361932 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY17_RS15155	356665..357378	+	714	WP_000123659.1	Fic family protein	-
HPY17_RS15160	357647..358579	+	933	WP_002044844.1	hypothetical protein	-
HPY17_RS15165	358563..358991	+	429	WP_000082746.1	hypothetical protein	-
HPY17_RS15170	359495..359629	+	135	WP_175247783.1	DUF3265 domain-containing protein	-
HPY17_RS15175	359616..360131	+	516	WP_076025898.1	MazG-related protein	-
HPY17_RS15180	360339..361250	+	912	WP_175247652.1	hypothetical protein	-
HPY17_RS15185	361262..361432	+	171	WP_175247653.1	hypothetical protein	-
HPY17_RS15190	361651..361932	+	282	WP_175247654.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HPY17_RS15195	361929..362216	+	288	WP_175247655.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY17_RS15200	362374..362838	+	465	WP_076025888.1	ASCH domain-containing protein	-
HPY17_RS15205	362903..362986	+	84	Protein_332	disulfide bond formation protein DsbD	-
HPY17_RS15210	362984..363400	+	417	WP_069730442.1	DUF1311 domain-containing protein	-
HPY17_RS15215	363718..363936	+	219	Protein_334	DUF645 family protein	-
HPY17_RS15220	364132..364368	-	237	WP_000772130.1	RNA-binding protein	-
HPY17_RS15225	364622..364891	-	270	WP_000277238.1	type II toxin-antitoxin system YafQ family toxin	-
HPY17_RS15230	364884..365162	-	279	WP_001258569.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
HPY17_RS15235	365916..366656	+	741	WP_162813548.1	PhzF family phenazine biosynthesis protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	310054..510566	200512
	-	inside	Integron	-	-	311218..510566	199348

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-73)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11059.82 Da
• Isoelectric Point: 6.0710

>T158033 WP_175247655.1 NZ_CP053817:361929-362216 [Vibrio cholerae]
MKVVWSPLALQKLGDVAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSFSHEIRV
LTVRNCRQLLTEHDV

Nucleotide

• Length: 288 bp

>T158033 NZ_CP069549:1330551-1330658 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCGTGATTTTCTGGCACGACCTGGCAGCACCGATCCTTGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10347.90 Da
• Isoelectric Point: 5.1548

>AT158033 WP_175247654.1 NZ_CP053817:361651-361932 [Vibrio cholerae]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTGEAQLAAGLGISN
EDARSQVLGRIIK

Nucleotide

• Length: 282 bp

>AT158033 NZ_CP069549:c1330490-1330435 [Escherichia coli]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTTGACCTCTCAACGTGCGGGGGTTTTC