Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 347305..347843 Replicon chromosome
Accession NZ_CP053817
Organism Vibrio cholerae strain SA7G

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag HPY17_RS15085 Protein ID WP_000802136.1
Coordinates 347305..347604 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag HPY17_RS15090 Protein ID WP_001107719.1
Coordinates 347601..347843 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY17_RS15060 343350..343904 + 555 WP_175247638.1 hypothetical protein -
HPY17_RS15065 343901..344071 + 171 WP_175247723.1 DUF3265 domain-containing protein -
HPY17_RS15070 344047..344361 + 315 WP_000248692.1 DUF4144 domain-containing protein -
HPY17_RS15075 345245..345889 + 645 WP_043990331.1 hypothetical protein -
HPY17_RS15080 346129..346629 + 501 WP_175247639.1 hypothetical protein -
HPY17_RS15085 347305..347604 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY17_RS15090 347601..347843 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
HPY17_RS15095 348517..348864 + 348 WP_175247640.1 hypothetical protein -
HPY17_RS15100 349156..349337 + 182 Protein_311 DUF645 family protein -
HPY17_RS15105 349554..350306 + 753 WP_000116045.1 SDR family oxidoreductase -
HPY17_RS15110 350535..350717 + 183 WP_095482486.1 DUF645 family protein -
HPY17_RS15115 350909..352090 - 1182 WP_175247641.1 DNA (cytosine-5-)-methyltransferase -
HPY17_RS15120 352090..352638 - 549 WP_175247642.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 310054..510566 200512
- inside Integron - - 311218..510566 199348


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T158032 WP_000802136.1 NZ_CP053817:c347604-347305 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T158032 NZ_CP069549:1109776-1110054 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT158032 WP_001107719.1 NZ_CP053817:c347843-347601 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT158032 NZ_CP069549:1110054-1110338 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCGGAA
AAAACGGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
PDB 7R5A
PDB 7B22
AlphaFold DB A0A151JFU4

References