Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 318634..319132 Replicon chromosome
Accession NZ_CP053817
Organism Vibrio cholerae strain SA7G

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag HPY17_RS14840 Protein ID WP_000589156.1
Coordinates 318634..318900 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID D7HCY3
Locus tag HPY17_RS14845 Protein ID WP_000643600.1
Coordinates 318887..319132 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY17_RS14815 314784..315017 + 234 WP_010319470.1 DUF3709 domain-containing protein -
HPY17_RS14820 315296..315763 + 468 WP_101412260.1 DUF1643 domain-containing protein -
HPY17_RS14825 315925..317424 - 1500 WP_175246408.1 hypothetical protein -
HPY17_RS14830 317740..317892 + 153 WP_114774755.1 DUF645 family protein -
HPY17_RS14835 318302..318397 + 96 WP_001907607.1 DUF645 family protein -
HPY17_RS14840 318634..318900 + 267 WP_000589156.1 BrnT family toxin Toxin
HPY17_RS14845 318887..319132 + 246 WP_000643600.1 hypothetical protein Antitoxin
HPY17_RS14850 319313..319663 - 351 WP_001086649.1 hypothetical protein -
HPY17_RS14855 319670..320959 - 1290 WP_175246596.1 hypothetical protein -
HPY17_RS14860 321314..321439 + 126 WP_175246597.1 DUF3709 domain-containing protein -
HPY17_RS14865 321457..321717 + 261 WP_032473168.1 DUF3709 domain-containing protein -
HPY17_RS14870 321944..322170 + 227 Protein_265 hypothetical protein -
HPY17_RS14875 322292..322402 + 111 WP_095462449.1 DUF3265 domain-containing protein -
HPY17_RS14880 322562..322735 + 174 WP_175246437.1 DUF3709 domain-containing protein -
HPY17_RS14885 323070..323933 + 864 WP_175246436.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 310054..510566 200512
- inside Integron - - 311218..510566 199348


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T158030 WP_000589156.1 NZ_CP053817:318634-318900 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T158030 NZ_CP069549:792822-792924 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9446.71 Da        Isoelectric Point: 6.4832

>AT158030 WP_000643600.1 NZ_CP053817:318887-319132 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVVDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT158030 NZ_CP069549:c792962-792694 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VMP7

Antitoxin

Source ID Structure
AlphaFold DB D7HCY3

References