Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc(toxin) |
| Location | 524914..525485 | Replicon | chromosome |
| Accession | NZ_CP053814 | ||
| Organism | Vibrio cholerae strain W7G | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | Q9KMA2 |
| Locus tag | HPY09_RS16530 | Protein ID | WP_000351248.1 |
| Coordinates | 525084..525485 (+) | Length | 134 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | Q8GNG3 |
| Locus tag | HPY09_RS16525 | Protein ID | WP_001080654.1 |
| Coordinates | 524914..525084 (+) | Length | 57 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY09_RS16485 | 519997..520403 | + | 407 | Protein_600 | VOC family protein | - |
| HPY09_RS16490 | 520551..520985 | + | 435 | WP_057563745.1 | GNAT family N-acetyltransferase | - |
| HPY09_RS16495 | 521176..521442 | + | 267 | WP_000589156.1 | BrnT family toxin | - |
| HPY09_RS16500 | 521429..521674 | + | 246 | WP_071180555.1 | CopG family transcriptional regulator | - |
| HPY09_RS16505 | 521817..522317 | + | 501 | WP_000686370.1 | NAD(P)H-dependent oxidoreductase | - |
| HPY09_RS16510 | 522589..522777 | + | 189 | WP_080483779.1 | DUF3709 domain-containing protein | - |
| HPY09_RS16515 | 522974..523933 | - | 960 | Protein_606 | IS30 family transposase | - |
| HPY09_RS16520 | 524219..524734 | + | 516 | WP_000284464.1 | hypothetical protein | - |
| HPY09_RS16525 | 524914..525084 | + | 171 | WP_001080654.1 | hypothetical protein | Antitoxin |
| HPY09_RS16530 | 525084..525485 | + | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| HPY09_RS16535 | 525758..525940 | + | 183 | WP_000093413.1 | DUF645 family protein | - |
| HPY09_RS16540 | 526137..526607 | - | 471 | WP_000784954.1 | RES family NAD+ phosphorylase | - |
| HPY09_RS16545 | 526607..527059 | - | 453 | WP_000024295.1 | DUF2384 domain-containing protein | - |
| HPY09_RS16550 | 527281..527757 | + | 477 | WP_001047175.1 | GNAT family N-acetyltransferase | - |
| HPY09_RS16555 | 528098..528225 | + | 128 | Protein_614 | DUF645 family protein | - |
| HPY09_RS16560 | 528212..528646 | + | 435 | WP_095462747.1 | IS200/IS605 family transposase | - |
| HPY09_RS16565 | 528725..529198 | - | 474 | WP_000034756.1 | FKBP-type peptidyl-prolyl cis-trans isomerase | - |
| HPY09_RS16570 | 529420..530034 | + | 615 | WP_162808162.1 | OmpA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 317876..527757 | 209881 | |
| - | inside | IScluster/Tn | - | - | 522974..528646 | 5672 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 134 a.a. Molecular weight: 14608.71 Da Isoelectric Point: 4.0128
>T158029 WP_000351248.1 NZ_CP053814:525084-525485 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL
Download Length: 402 bp
>T158029 NZ_CP069549:602115-602447 [Escherichia coli]
ATGGACAGAGGGGAAATCTGGCTGGTTTCACTGGATCCGATTGCAGGTCACGAGCAAAGCGGAAAACGTCCGGTGCTTAT
CGTATCGAAGGCATCGTTTAACAAGCTGACCCGGCTACCCGTTGTTGTTCCCGTTACCAGCGGCGGAAACTTCGCCCGTG
CAGCCGGTTTTACCGTCTCACTGGACGGTGCGGGAACAAAAACAACGGGCGTTATTCGCTGCGACCAGCCCAGAACCATT
GATATGGGAGCCCGGAGCGGTAAGCGACTGGAACGTATACCCGATGCTGTCGTGAATGAAGTGCTGGCCCGACTGGAGGC
CATTCTGAGCTGA
ATGGACAGAGGGGAAATCTGGCTGGTTTCACTGGATCCGATTGCAGGTCACGAGCAAAGCGGAAAACGTCCGGTGCTTAT
CGTATCGAAGGCATCGTTTAACAAGCTGACCCGGCTACCCGTTGTTGTTCCCGTTACCAGCGGCGGAAACTTCGCCCGTG
CAGCCGGTTTTACCGTCTCACTGGACGGTGCGGGAACAAAAACAACGGGCGTTATTCGCTGCGACCAGCCCAGAACCATT
GATATGGGAGCCCGGAGCGGTAAGCGACTGGAACGTATACCCGATGCTGTCGTGAATGAAGTGCTGGCCCGACTGGAGGC
CATTCTGAGCTGA
Antitoxin
Download Length: 57 a.a. Molecular weight: 6287.35 Da Isoelectric Point: 10.7274
>AT158029 WP_001080654.1 NZ_CP053814:524914-525084 [Vibrio cholerae]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM
Download Length: 171 bp
>AT158029 NZ_CP069549:601857-602114 [Escherichia coli]
ATGTATACAACTCGCCTGAAAAAGGTCGGCGGATCCATCATGCTGGCGGTTCCCCCCGCCGTGCTGAAAACGCTGGAGCT
GTCGACGGACAGCGAAGTGGGTATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGTTATTCGC
TTGAGGAGTTGTTGGCGCAGTGCGATCCGCACGCAGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATCCTGTAA
ATGTATACAACTCGCCTGAAAAAGGTCGGCGGATCCATCATGCTGGCGGTTCCCCCCGCCGTGCTGAAAACGCTGGAGCT
GTCGACGGACAGCGAAGTGGGTATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGTTATTCGC
TTGAGGAGTTGTTGGCGCAGTGCGATCCGCACGCAGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATCCTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0Q0PN34 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1T4SJJ1 |