Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /GNAT-DUF1778 |
| Location | 509428..510194 | Replicon | chromosome |
| Accession | NZ_CP053814 | ||
| Organism | Vibrio cholerae strain W7G | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | HPY09_RS16390 | Protein ID | WP_033932155.1 |
| Coordinates | 509428..509925 (-) | Length | 166 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0Q0PQR2 |
| Locus tag | HPY09_RS16395 | Protein ID | WP_000246255.1 |
| Coordinates | 509922..510194 (-) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY09_RS16350 | 504866..505381 | + | 516 | WP_175247206.1 | MazG-related protein | - |
| HPY09_RS16355 | 505522..505956 | + | 435 | WP_044128155.1 | GNAT family N-acetyltransferase | - |
| HPY09_RS16360 | 506092..506409 | - | 318 | WP_175247207.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY09_RS16365 | 506428..506670 | - | 243 | WP_001961623.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY09_RS16370 | 507386..507901 | + | 516 | WP_175247206.1 | MazG-related protein | - |
| HPY09_RS16375 | 508042..508476 | + | 435 | WP_044128155.1 | GNAT family N-acetyltransferase | - |
| HPY09_RS16380 | 508612..508929 | - | 318 | WP_175247207.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY09_RS16385 | 508948..509190 | - | 243 | WP_001961623.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY09_RS16390 | 509428..509925 | - | 498 | WP_033932155.1 | GNAT family N-acetyltransferase | Toxin |
| HPY09_RS16395 | 509922..510194 | - | 273 | WP_000246255.1 | DUF1778 domain-containing protein | Antitoxin |
| HPY09_RS16400 | 510582..510764 | + | 183 | WP_032479935.1 | DUF645 family protein | - |
| HPY09_RS16405 | 511206..511373 | + | 168 | WP_001883086.1 | DUF3265 domain-containing protein | - |
| HPY09_RS16410 | 511515..511604 | + | 90 | WP_113624546.1 | DUF645 family protein | - |
| HPY09_RS16415 | 511608..511634 | + | 27 | Protein_586 | hypothetical protein | - |
| HPY09_RS16420 | 511837..512292 | + | 456 | WP_071180673.1 | GNAT family N-acetyltransferase | - |
| HPY09_RS16425 | 512437..512901 | + | 465 | WP_071180674.1 | ASCH domain-containing protein | - |
| HPY09_RS16430 | 513047..513406 | + | 360 | WP_071180081.1 | nuclear transport factor 2 family protein | - |
| HPY09_RS16435 | 513632..514345 | + | 714 | WP_175247208.1 | Fic family protein | - |
| HPY09_RS16440 | 514641..514823 | + | 183 | WP_033933234.1 | DUF645 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 317876..527757 | 209881 | |
| - | inside | Genomic island | - | - | 489128..513406 | 24278 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 166 a.a. Molecular weight: 18512.20 Da Isoelectric Point: 8.7753
>T158027 WP_033932155.1 NZ_CP053814:c509925-509428 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFSCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG
MMNTVLLDKDKHDRNRFSCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG
Download Length: 498 bp
>T158027 NZ_CP069549:548344-548595 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
Antitoxin
Download Length: 91 a.a. Molecular weight: 9713.24 Da Isoelectric Point: 6.2988
>AT158027 WP_000246255.1 NZ_CP053814:c510194-509922 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ
MATTLPRITARVDVDTQDLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ
Download Length: 273 bp
>AT158027 NZ_CP069549:548592-548846 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|