Detailed information of TA system TA158025

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-Phd
• Location: 506092..506670
• Replicon: chromosome
• Accession: NZ_CP053814
• Organism: Vibrio cholerae strain W7G

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: HPY09_RS16360
• Protein ID: WP_175247207.1
• Coordinates: 506092..506409 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: HPY09_RS16365
• Protein ID: WP_001961623.1
• Coordinates: 506428..506670 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY09_RS16330	501389..502189	+	801	Protein_569	PhzF family phenazine biosynthesis protein	-
HPY09_RS16335	502331..503146	+	816	WP_071179752.1	hypothetical protein	-
HPY09_RS16340	503288..503722	+	435	WP_000453961.1	GNAT family N-acetyltransferase	-
HPY09_RS16345	504083..504202	+	120	Protein_572	DUF645 family protein	-
HPY09_RS16350	504866..505381	+	516	WP_175247206.1	MazG-related protein	-
HPY09_RS16355	505522..505956	+	435	WP_044128155.1	GNAT family N-acetyltransferase	-
HPY09_RS16360	506092..506409	-	318	WP_175247207.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY09_RS16365	506428..506670	-	243	WP_001961623.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HPY09_RS16370	507386..507901	+	516	WP_175247206.1	MazG-related protein	-
HPY09_RS16375	508042..508476	+	435	WP_044128155.1	GNAT family N-acetyltransferase	-
HPY09_RS16380	508612..508929	-	318	WP_175247207.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HPY09_RS16385	508948..509190	-	243	WP_001961623.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
HPY09_RS16390	509428..509925	-	498	WP_033932155.1	GNAT family N-acetyltransferase	-
HPY09_RS16395	509922..510194	-	273	WP_000246255.1	DUF1778 domain-containing protein	-
HPY09_RS16400	510582..510764	+	183	WP_032479935.1	DUF645 family protein	-
HPY09_RS16405	511206..511373	+	168	WP_001883086.1	DUF3265 domain-containing protein	-
HPY09_RS16410	511515..511604	+	90	WP_113624546.1	DUF645 family protein	-
HPY09_RS16415	511608..511634	+	27	Protein_586	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	317876..527757	209881
	-	inside	Genomic island	-	-	489128..513406	24278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12159.02 Da
• Isoelectric Point: 9.8987

>T158025 WP_175247207.1 NZ_CP053814:c506409-506092 [Vibrio cholerae]
MKNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Nucleotide

• Length: 318 bp

>T158025 NZ_CP069542:c4878493-4878320 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8931.22 Da
• Isoelectric Point: 5.6630

>AT158025 WP_001961623.1 NZ_CP053814:c506670-506428 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDGGKTVDGATFLNTL

Nucleotide

• Length: 243 bp

>AT158025 NZ_CP069542:c4878817-4878521 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG