Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-Phd |
| Location | 490626..491173 | Replicon | chromosome |
| Accession | NZ_CP053814 | ||
| Organism | Vibrio cholerae strain W7G | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A0Q0PYS1 |
| Locus tag | HPY09_RS16245 | Protein ID | WP_000229322.1 |
| Coordinates | 490871..491173 (+) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9KM93 |
| Locus tag | HPY09_RS16240 | Protein ID | WP_000861987.1 |
| Coordinates | 490626..490883 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY09_RS16200 | 485697..486200 | + | 504 | WP_001158952.1 | DinB family protein | - |
| HPY09_RS16205 | 486341..487162 | + | 822 | WP_175247201.1 | DUF2806 domain-containing protein | - |
| HPY09_RS16210 | 487312..487815 | + | 504 | WP_139284506.1 | hypothetical protein | - |
| HPY09_RS16215 | 488534..488752 | + | 219 | WP_044128180.1 | DUF3709 domain-containing protein | - |
| HPY09_RS16220 | 489128..489364 | + | 237 | WP_175247202.1 | hypothetical protein | - |
| HPY09_RS16225 | 489688..489867 | + | 180 | WP_175247344.1 | DUF645 family protein | - |
| HPY09_RS16230 | 489983..490096 | + | 114 | WP_175247203.1 | acetyltransferase | - |
| HPY09_RS16235 | 490045..490326 | + | 282 | WP_080368113.1 | DUF1289 domain-containing protein | - |
| HPY09_RS16240 | 490626..490883 | + | 258 | WP_000861987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| HPY09_RS16245 | 490871..491173 | + | 303 | WP_000229322.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HPY09_RS16250 | 491386..491649 | + | 264 | WP_071180065.1 | hypothetical protein | - |
| HPY09_RS16255 | 491970..492152 | + | 183 | WP_080483772.1 | DUF645 family protein | - |
| HPY09_RS16260 | 492350..492898 | + | 549 | WP_053543578.1 | hypothetical protein | - |
| HPY09_RS16265 | 493182..493403 | + | 222 | WP_081017977.1 | DUF3709 domain-containing protein | - |
| HPY09_RS16270 | 493690..494328 | + | 639 | WP_175247204.1 | hypothetical protein | - |
| HPY09_RS16275 | 494615..494797 | + | 183 | WP_033933192.1 | DUF645 family protein | - |
| HPY09_RS16280 | 495100..495210 | + | 111 | WP_080483846.1 | DUF645 family protein | - |
| HPY09_RS16285 | 495232..495267 | + | 36 | WP_108248532.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 317876..527757 | 209881 | |
| - | inside | Genomic island | - | - | 489128..513406 | 24278 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11737.67 Da Isoelectric Point: 5.1972
>T158024 WP_000229322.1 NZ_CP053814:490871-491173 [Vibrio cholerae]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ
Download Length: 303 bp
>T158024 NZ_CP069542:c4646631-4646257 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9647.15 Da Isoelectric Point: 7.3178
>AT158024 WP_000861987.1 NZ_CP053814:490626-490883 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
Download Length: 258 bp
>AT158024 NZ_CP069542:c4647089-4646721 [Escherichia coli]
GTGTTAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGATCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTACTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATTCGACGCCCGAAACGAAAAAGTAA
GTGTTAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGATCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTACTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATTCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0Q0PYS1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1T4SLM9 |