Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 474473..475032 | Replicon | chromosome |
| Accession | NZ_CP053814 | ||
| Organism | Vibrio cholerae strain W7G | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D7HHK2 |
| Locus tag | HPY09_RS16105 | Protein ID | WP_000578471.1 |
| Coordinates | 474473..474751 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9L991 |
| Locus tag | HPY09_RS16110 | Protein ID | WP_000381183.1 |
| Coordinates | 474748..475032 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY09_RS16065 | 469801..469980 | + | 180 | WP_005522103.1 | DUF645 family protein | - |
| HPY09_RS16070 | 470159..470644 | + | 486 | WP_000495105.1 | GNAT family N-acetyltransferase | - |
| HPY09_RS16075 | 470673..471632 | - | 960 | WP_001107099.1 | IS30 family transposase | - |
| HPY09_RS16080 | 471885..472262 | + | 378 | WP_000798825.1 | hypothetical protein | - |
| HPY09_RS16085 | 472416..472880 | + | 465 | WP_000392739.1 | ASCH domain-containing protein | - |
| HPY09_RS16090 | 473158..473394 | + | 237 | WP_071170843.1 | DUF3709 domain-containing protein | - |
| HPY09_RS16095 | 473661..473977 | - | 317 | Protein_522 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY09_RS16100 | 473996..474238 | - | 243 | WP_001961623.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY09_RS16105 | 474473..474751 | - | 279 | WP_000578471.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| HPY09_RS16110 | 474748..475032 | - | 285 | WP_000381183.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| HPY09_RS16115 | 475266..475502 | - | 237 | WP_000772125.1 | RNA-binding protein | - |
| HPY09_RS16120 | 475801..476124 | + | 324 | WP_001886489.1 | DUF3709 domain-containing protein | - |
| HPY09_RS16125 | 476996..477148 | + | 153 | WP_161803584.1 | DUF3709 domain-containing protein | - |
| HPY09_RS16130 | 477588..477698 | + | 111 | WP_080483846.1 | DUF645 family protein | - |
| HPY09_RS16135 | 477720..477755 | + | 36 | WP_108248532.1 | hypothetical protein | - |
| HPY09_RS16140 | 478069..478494 | + | 426 | WP_001898445.1 | hypothetical protein | - |
| HPY09_RS16145 | 478638..479000 | + | 363 | WP_175247343.1 | DUF4144 domain-containing protein | - |
| HPY09_RS16150 | 479161..479625 | + | 465 | WP_000392739.1 | ASCH domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 317876..527757 | 209881 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10838.56 Da Isoelectric Point: 4.6794
>T158022 WP_000578471.1 NZ_CP053814:c474751-474473 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
Download Length: 279 bp
>T158022 NZ_CP069542:c4590235-4589948 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10901.25 Da Isoelectric Point: 8.0775
>AT158022 WP_000381183.1 NZ_CP053814:c475032-474748 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
Download Length: 285 bp
>AT158022 NZ_CP069542:c4589961-4589659 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGACGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGACGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A271VKS2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A067BL33 |