Detailed information of TA system TA158019

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 431161..431689
• Replicon: chromosome
• Accession: NZ_CP053814
• Organism: Vibrio cholerae strain W7G

Toxin (Protein)

• Gene name: relE
• Uniprot ID: H9L4R3
• Locus tag: HPY09_RS15730
• Protein ID: WP_000221352.1
• Coordinates: 431161..431451 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HPY09_RS15735
• Protein ID: WP_000213182.1
• Coordinates: 431441..431689 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY09_RS15685	426249..426359	+	111	WP_072599465.1	DUF3265 domain-containing protein	-
HPY09_RS15690	426392..426925	+	534	WP_069217114.1	GNAT family N-acetyltransferase	-
HPY09_RS15695	427393..427503	+	111	WP_072599357.1	DUF3265 domain-containing protein	-
HPY09_RS15700	427511..427810	-	300	WP_000802134.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HPY09_RS15705	427807..428049	-	243	WP_001107720.1	type II toxin-antitoxin system ParD family antitoxin	-
HPY09_RS15710	428408..428626	+	219	WP_044128180.1	DUF3709 domain-containing protein	-
HPY09_RS15715	428906..429589	+	684	WP_001010781.1	hypothetical protein	-
HPY09_RS15720	429728..430501	+	774	WP_175247187.1	NERD domain-containing protein	-
HPY09_RS15725	430794..430976	+	183	Protein_448	DUF645 family protein	-
HPY09_RS15730	431161..431451	-	291	WP_000221352.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY09_RS15735	431441..431689	-	249	WP_000213182.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HPY09_RS15740	431928..432380	+	453	WP_020196891.1	hypothetical protein	-
HPY09_RS15745	432377..432487	+	111	WP_175247337.1	DUF3265 domain-containing protein	-
HPY09_RS15750	432468..432830	+	363	WP_175247338.1	DUF4144 domain-containing protein	-
HPY09_RS15755	432936..433097	+	162	Protein_454	DUF3709 domain-containing protein	-
HPY09_RS15760	433118..433351	+	234	WP_142737015.1	DUF3709 domain-containing protein	-
HPY09_RS15765	433620..433889	-	270	WP_000277238.1	type II toxin-antitoxin system YafQ family toxin	-
HPY09_RS15770	433882..434160	-	279	WP_001258569.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
HPY09_RS15775	434318..434971	+	654	WP_175247339.1	hypothetical protein	-
HPY09_RS15780	435062..435222	+	161	Protein_459	DUF3709 domain-containing protein	-
HPY09_RS15785	435243..435476	+	234	WP_175247188.1	DUF3709 domain-containing protein	-
HPY09_RS15790	435903..435992	+	90	WP_141239104.1	DUF645 family protein	-
HPY09_RS15795	435995..436084	+	90	Protein_462	DUF645 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	317876..527757	209881

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11247.23 Da
• Isoelectric Point: 10.4678

>T158019 WP_000221352.1 NZ_CP053814:c431451-431161 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Nucleotide

• Length: 291 bp

>T158019 NZ_CP069542:c4199033-4198665 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCTCCGGCGGCGAAGCCCTGTCCGTCGCCCGTTGCAGTCTGGCAAATGTTACTTAC
TCGTTTGCTTGAGCAGCACTATGGCCTAATGCTAAGCGACACACCTTTTAGCGATGAAACCGTTATAAAGGAGCATATTG
ATGCCGGTATCACTCTGGCTAATGCCGTTAACTTTCTGGTAGAGAAATATGAGTTAGTTCGTATTGATCGCAATGGATTT
ACCTCTCAGGTACAAGCACCATATTTGACTGCGACAGACATTCTTCAAGCCAGGAAAGCGTGCGGGTTGATGAGCCGGTG
TTCTTACAGAGATGTAAGTAATATTGTTCTTAGCCGATCACGGTTGTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8964.31 Da
• Isoelectric Point: 4.1079

>AT158019 WP_000213182.1 NZ_CP053814:c431689-431441 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPANTYELMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Nucleotide

• Length: 249 bp

>AT158019 NZ_CP069542:c4199359-4199054 [Escherichia coli]
CTGGTGGGGCTACCCTACACCGTGACGCCCTGTTCTGGCACCCGTCTGGTGCAGGAGGGCAACCGACTGTACTATTTGGC
TGACCGGGCAAGTATCACCGGTAAGTTTAGTGATGCCGAAAGCCTGAAGCTGGATGTCGTATTTCCACATTTTATCAGTC
AGATGGAATCGATGCTGACCACTGGTGAAATGAATCCCCGCCATGCCCACTGTTTCACCCTGTACCACAACGGTTTCACC
TGCGAAGCCGATACCCTTGGTAGTTGCGGCTATGTATACATCGCCATTTATCCCACTCAGCTCTAA

Structures

Toxin

• AlphaFold DB: H9L4R3