Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 427511..428049 | Replicon | chromosome |
| Accession | NZ_CP053814 | ||
| Organism | Vibrio cholerae strain W7G | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | HPY09_RS15700 | Protein ID | WP_000802134.1 |
| Coordinates | 427511..427810 (-) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A271VK51 |
| Locus tag | HPY09_RS15705 | Protein ID | WP_001107720.1 |
| Coordinates | 427807..428049 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY09_RS15660 | 423219..423857 | + | 639 | WP_095472335.1 | hypothetical protein | - |
| HPY09_RS15665 | 423985..424302 | - | 318 | WP_000077449.1 | CcdB family protein | - |
| HPY09_RS15670 | 424302..424547 | - | 246 | WP_001260797.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| HPY09_RS15675 | 424849..425085 | + | 237 | WP_175247186.1 | DUF645 family protein | - |
| HPY09_RS15680 | 425284..425775 | + | 492 | WP_005527260.1 | hypothetical protein | - |
| HPY09_RS15685 | 426249..426359 | + | 111 | WP_072599465.1 | DUF3265 domain-containing protein | - |
| HPY09_RS15690 | 426392..426925 | + | 534 | WP_069217114.1 | GNAT family N-acetyltransferase | - |
| HPY09_RS15695 | 427393..427503 | + | 111 | WP_072599357.1 | DUF3265 domain-containing protein | - |
| HPY09_RS15700 | 427511..427810 | - | 300 | WP_000802134.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HPY09_RS15705 | 427807..428049 | - | 243 | WP_001107720.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| HPY09_RS15710 | 428408..428626 | + | 219 | WP_044128180.1 | DUF3709 domain-containing protein | - |
| HPY09_RS15715 | 428906..429589 | + | 684 | WP_001010781.1 | hypothetical protein | - |
| HPY09_RS15720 | 429728..430501 | + | 774 | WP_175247187.1 | NERD domain-containing protein | - |
| HPY09_RS15725 | 430794..430976 | + | 183 | Protein_448 | DUF645 family protein | - |
| HPY09_RS15730 | 431161..431451 | - | 291 | WP_000221352.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY09_RS15735 | 431441..431689 | - | 249 | WP_000213182.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY09_RS15740 | 431928..432380 | + | 453 | WP_020196891.1 | hypothetical protein | - |
| HPY09_RS15745 | 432377..432487 | + | 111 | WP_175247337.1 | DUF3265 domain-containing protein | - |
| HPY09_RS15750 | 432468..432830 | + | 363 | WP_175247338.1 | DUF4144 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 317876..527757 | 209881 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11601.34 Da Isoelectric Point: 9.9232
>T158018 WP_000802134.1 NZ_CP053814:c427810-427511 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQIGSQQ
IRVIRILHKSMDVNPIFGA
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQIGSQQ
IRVIRILHKSMDVNPIFGA
Download Length: 300 bp
>T158018 NZ_CP069542:4015515-4015733 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8950.82 Da Isoelectric Point: 4.1677
>AT158018 WP_001107720.1 NZ_CP053814:c428049-427807 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLVEGEQSGDADYDLDSFINELDSENIR
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLVEGEQSGDADYDLDSFINELDSENIR
Download Length: 243 bp
>AT158018 NZ_CP069542:4015115-4015489 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|