Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 407161..407739 Replicon chromosome
Accession NZ_CP053814
Organism Vibrio cholerae strain W7G

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag HPY09_RS15525 Protein ID WP_001180243.1
Coordinates 407161..407478 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag HPY09_RS15530 Protein ID WP_001961623.1
Coordinates 407497..407739 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY09_RS15490 402852..403277 + 426 WP_000415750.1 hypothetical protein -
HPY09_RS15495 403458..403748 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY09_RS15500 403738..403986 - 249 WP_000213182.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HPY09_RS15505 404178..404666 + 489 WP_175247181.1 GNAT family N-acetyltransferase -
HPY09_RS15510 404809..405444 + 636 WP_069648801.1 hypothetical protein -
HPY09_RS15515 405771..405950 + 180 WP_050547145.1 DUF645 family protein -
HPY09_RS15520 406784..406965 + 182 Protein_407 DUF645 family protein -
HPY09_RS15525 407161..407478 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY09_RS15530 407497..407739 - 243 WP_001961623.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HPY09_RS15535 408062..408310 + 249 WP_175247182.1 DUF645 family protein -
HPY09_RS15540 408600..408707 + 108 Protein_411 ggdef family protein -
HPY09_RS15545 409178..409330 + 153 WP_161803584.1 DUF3709 domain-containing protein -
HPY09_RS15550 409794..410000 + 207 Protein_413 DUF645 family protein -
HPY09_RS15555 410212..411216 + 1005 WP_000964931.1 LD-carboxypeptidase -
HPY09_RS15560 411510..411692 + 183 WP_114763558.1 DUF645 family protein -
HPY09_RS15565 412047..412229 + 183 Protein_416 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 317876..527757 209881


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T158017 WP_001180243.1 NZ_CP053814:c407478-407161 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T158017 NZ_CP069542:3175810-3175917 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8931.22 Da        Isoelectric Point: 5.6630

>AT158017 WP_001961623.1 NZ_CP053814:c407739-407497 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDGGKTVDGATFLNTL

Download         Length: 243 bp

>AT158017 NZ_CP069542:c3175763-3175697 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure

References