158016

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 403458..403986 Replicon chromosome
Accession NZ_CP053814
Organism Vibrio cholerae strain W7G

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag HPY09_RS15495 Protein ID WP_000221352.1
Coordinates 403458..403748 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HPY09_RS15500 Protein ID WP_000213182.1
Coordinates 403738..403986 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY09_RS15455 398494..398907 + 414 WP_000049417.1 VOC family protein -
HPY09_RS15460 399563..400771 + 1209 WP_158160342.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
HPY09_RS15465 400781..400891 + 111 WP_082798410.1 DUF3265 domain-containing protein -
HPY09_RS15470 400954..401238 + 285 WP_000048765.1 antibiotic biosynthesis monooxygenase -
HPY09_RS15475 401668..401790 + 123 WP_082321036.1 DUF3265 domain-containing protein -
HPY09_RS15480 401967..402053 + 87 WP_175247335.1 DUF645 family protein -
HPY09_RS15485 402053..402145 + 93 Protein_400 DUF645 family protein -
HPY09_RS15490 402852..403277 + 426 WP_000415750.1 hypothetical protein -
HPY09_RS15495 403458..403748 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY09_RS15500 403738..403986 - 249 WP_000213182.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HPY09_RS15505 404178..404666 + 489 WP_175247181.1 GNAT family N-acetyltransferase -
HPY09_RS15510 404809..405444 + 636 WP_069648801.1 hypothetical protein -
HPY09_RS15515 405771..405950 + 180 WP_050547145.1 DUF645 family protein -
HPY09_RS15520 406784..406965 + 182 Protein_407 DUF645 family protein -
HPY09_RS15525 407161..407478 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY09_RS15530 407497..407739 - 243 WP_001961623.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HPY09_RS15535 408062..408310 + 249 WP_175247182.1 DUF645 family protein -
HPY09_RS15540 408600..408707 + 108 Protein_411 ggdef family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 317876..527757 209881


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T158016 WP_000221352.1 NZ_CP053814:c403748-403458 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T158016 NZ_CP069542:3175275-3175382 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8964.31 Da        Isoelectric Point: 4.1079

>AT158016 WP_000213182.1 NZ_CP053814:c403986-403738 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPANTYELMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT158016 NZ_CP069542:c3175228-3175162 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure

References