158014

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 1148139..1148902 Replicon chromosome
Accession NZ_CP053813
Organism Vibrio cholerae strain W7G

Toxin (Protein)


Gene name ataT Uniprot ID A0A5B0H076
Locus tag HPY09_RS05400 Protein ID WP_032475876.1
Coordinates 1148139..1148645 (-) Length 169 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A2K9A963
Locus tag HPY09_RS05405 Protein ID WP_001963895.1
Coordinates 1148636..1148902 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY09_RS05360 1143252..1143530 - 279 WP_000058216.1 helix-turn-helix domain-containing protein -
HPY09_RS05365 1143527..1143850 - 324 WP_001896384.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY09_RS05370 1144031..1144312 + 282 WP_000433891.1 type IV conjugative transfer system protein TraL -
HPY09_RS05375 1144309..1144935 + 627 WP_001896361.1 sex pilus assembly -
HPY09_RS05380 1144919..1145815 + 897 WP_032475897.1 type-F conjugative transfer system secretin TraK -
HPY09_RS05385 1145818..1147068 + 1251 WP_149519259.1 TraB/VirB10 family protein -
HPY09_RS05390 1147143..1147715 + 573 WP_142610872.1 TraV family lipoprotein -
HPY09_RS05395 1147712..1148098 + 387 WP_023584042.1 hypothetical protein -
HPY09_RS05400 1148139..1148645 - 507 WP_032475876.1 GNAT family N-acetyltransferase Toxin
HPY09_RS05405 1148636..1148902 - 267 WP_001963895.1 DUF1778 domain-containing protein Antitoxin
HPY09_RS05410 1149271..1149963 + 693 WP_175246836.1 DsbC family protein -
HPY09_RS05415 1149963..1152362 + 2400 WP_024008831.1 type IV secretion system protein TraC -
HPY09_RS05420 1152355..1152702 + 348 WP_152118583.1 plasmid-related protein -
HPY09_RS05425 1152686..1153198 + 513 WP_175246837.1 S26 family signal peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1128255..1229902 101647


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-146)

Antitoxin

Vibrio phage ICP1, Orf50

(8-83)


Sequences

Toxin        


Download         Length: 169 a.a.        Molecular weight: 18277.02 Da        Isoelectric Point: 7.7717

>T158014 WP_032475876.1 NZ_CP053813:c1148645-1148139 [Vibrio cholerae]
MGISAPTLLTDEHQLNAFQCGIEELNTWLRKQALKSQKRGTARVYVVNDTDAHQVVGYYAIAMGSVSREQAFSSLRRNSP
DPIPMVILARLGVDNAYQGQGIAAGLLKDCIIRSVQAMNAVGGAGILVHAIDGSAQTFYKKFGFKESTFDPLVLMARICD
IEKSLSID

Download         Length: 507 bp

>T158014 NZ_CP069542:2852783-2854105 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9969.47 Da        Isoelectric Point: 5.8580

>AT158014 WP_001963895.1 NZ_CP053813:c1148902-1148636 [Vibrio cholerae]
MATKTAPINMRVLPSVRDIIDAAASLKKVDRTVFIQQAALNEAHNVLAEQRDFVLEAKAFEAFDNELRAEPQTLEGMKDL
FKRKAPWE

Download         Length: 267 bp

>AT158014 NZ_CP069542:2852517-2852783 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5B0H076

Antitoxin

Source ID Structure
AlphaFold DB A0A2K9A963

References