Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /GNAT-DUF1778 |
| Location | 509405..510171 | Replicon | chromosome |
| Accession | NZ_CP053811 | ||
| Organism | Vibrio cholerae strain W6G | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | HPY05_RS16395 | Protein ID | WP_033932155.1 |
| Coordinates | 509405..509902 (-) | Length | 166 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0Q0PQR2 |
| Locus tag | HPY05_RS16400 | Protein ID | WP_000246255.1 |
| Coordinates | 509899..510171 (-) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY05_RS16355 | 504843..505358 | + | 516 | WP_175247206.1 | MazG-related protein | - |
| HPY05_RS16360 | 505499..505933 | + | 435 | WP_044128155.1 | GNAT family N-acetyltransferase | - |
| HPY05_RS16365 | 506069..506386 | - | 318 | WP_175247207.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY05_RS16370 | 506405..506647 | - | 243 | WP_001961623.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY05_RS16375 | 507363..507878 | + | 516 | WP_175247206.1 | MazG-related protein | - |
| HPY05_RS16380 | 508019..508453 | + | 435 | WP_044128155.1 | GNAT family N-acetyltransferase | - |
| HPY05_RS16385 | 508589..508906 | - | 318 | WP_175247207.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY05_RS16390 | 508925..509167 | - | 243 | WP_001961623.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY05_RS16395 | 509405..509902 | - | 498 | WP_033932155.1 | GNAT family N-acetyltransferase | Toxin |
| HPY05_RS16400 | 509899..510171 | - | 273 | WP_000246255.1 | DUF1778 domain-containing protein | Antitoxin |
| HPY05_RS16405 | 510559..510741 | + | 183 | WP_032479935.1 | DUF645 family protein | - |
| HPY05_RS16410 | 511183..511350 | + | 168 | WP_001883086.1 | DUF3265 domain-containing protein | - |
| HPY05_RS16415 | 511492..511581 | + | 90 | WP_113624546.1 | DUF645 family protein | - |
| HPY05_RS16420 | 511585..511611 | + | 27 | Protein_588 | hypothetical protein | - |
| HPY05_RS16425 | 511814..512269 | + | 456 | WP_071180673.1 | GNAT family N-acetyltransferase | - |
| HPY05_RS16430 | 512414..512878 | + | 465 | WP_071180674.1 | ASCH domain-containing protein | - |
| HPY05_RS16435 | 513024..513383 | + | 360 | WP_071180081.1 | nuclear transport factor 2 family protein | - |
| HPY05_RS16440 | 513609..514322 | + | 714 | WP_175247208.1 | Fic family protein | - |
| HPY05_RS16445 | 514618..514800 | + | 183 | WP_033933234.1 | DUF645 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 317868..527734 | 209866 | |
| - | inside | Genomic island | - | - | 489105..513383 | 24278 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 166 a.a. Molecular weight: 18512.20 Da Isoelectric Point: 8.7753
>T158010 WP_033932155.1 NZ_CP053811:c509902-509405 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFSCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG
MMNTVLLDKDKHDRNRFSCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG
Download Length: 498 bp
>T158010 NZ_CP069542:1467784-1468119 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
Antitoxin
Download Length: 91 a.a. Molecular weight: 9713.24 Da Isoelectric Point: 6.2988
>AT158010 WP_000246255.1 NZ_CP053811:c510171-509899 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ
MATTLPRITARVDVDTQDLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ
Download Length: 273 bp
>AT158010 NZ_CP069542:1467536-1467784 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|