158008

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 506069..506647 Replicon chromosome
Accession NZ_CP053811
Organism Vibrio cholerae strain W6G

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag HPY05_RS16365 Protein ID WP_175247207.1
Coordinates 506069..506386 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag HPY05_RS16370 Protein ID WP_001961623.1
Coordinates 506405..506647 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY05_RS16335 501366..502166 + 801 Protein_571 PhzF family phenazine biosynthesis protein -
HPY05_RS16340 502308..503123 + 816 WP_071179752.1 hypothetical protein -
HPY05_RS16345 503265..503699 + 435 WP_000453961.1 GNAT family N-acetyltransferase -
HPY05_RS16350 504060..504179 + 120 Protein_574 DUF645 family protein -
HPY05_RS16355 504843..505358 + 516 WP_175247206.1 MazG-related protein -
HPY05_RS16360 505499..505933 + 435 WP_044128155.1 GNAT family N-acetyltransferase -
HPY05_RS16365 506069..506386 - 318 WP_175247207.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY05_RS16370 506405..506647 - 243 WP_001961623.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HPY05_RS16375 507363..507878 + 516 WP_175247206.1 MazG-related protein -
HPY05_RS16380 508019..508453 + 435 WP_044128155.1 GNAT family N-acetyltransferase -
HPY05_RS16385 508589..508906 - 318 WP_175247207.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY05_RS16390 508925..509167 - 243 WP_001961623.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HPY05_RS16395 509405..509902 - 498 WP_033932155.1 GNAT family N-acetyltransferase -
HPY05_RS16400 509899..510171 - 273 WP_000246255.1 DUF1778 domain-containing protein -
HPY05_RS16405 510559..510741 + 183 WP_032479935.1 DUF645 family protein -
HPY05_RS16410 511183..511350 + 168 WP_001883086.1 DUF3265 domain-containing protein -
HPY05_RS16415 511492..511581 + 90 WP_113624546.1 DUF645 family protein -
HPY05_RS16420 511585..511611 + 27 Protein_588 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 317868..527734 209866
- inside Genomic island - - 489105..513383 24278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12159.02 Da        Isoelectric Point: 9.8987

>T158008 WP_175247207.1 NZ_CP053811:c506386-506069 [Vibrio cholerae]
MKNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T158008 NZ_CP069542:c1219360-1218983 [Escherichia coli]
ATGAAAACATTACCCGATACACTCGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACCGACCAGCCGGGGTTC
AGCACCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
AAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8931.22 Da        Isoelectric Point: 5.6630

>AT158008 WP_001961623.1 NZ_CP053811:c506647-506405 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDGGKTVDGATFLNTL

Download         Length: 243 bp

>AT158008 NZ_CP069542:c1219818-1219450 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTTGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References