Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 490603..491150 Replicon chromosome
Accession NZ_CP053811
Organism Vibrio cholerae strain W6G

Toxin (Protein)


Gene name relE Uniprot ID A0A0Q0PYS1
Locus tag HPY05_RS16250 Protein ID WP_000229322.1
Coordinates 490848..491150 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag HPY05_RS16245 Protein ID WP_000861987.1
Coordinates 490603..490860 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY05_RS16205 485674..486177 + 504 WP_001158952.1 DinB family protein -
HPY05_RS16210 486318..487139 + 822 WP_175247201.1 DUF2806 domain-containing protein -
HPY05_RS16215 487289..487792 + 504 WP_139284506.1 hypothetical protein -
HPY05_RS16220 488511..488729 + 219 WP_044128180.1 DUF3709 domain-containing protein -
HPY05_RS16225 489105..489341 + 237 WP_175247202.1 hypothetical protein -
HPY05_RS16230 489665..489844 + 180 WP_175247344.1 DUF645 family protein -
HPY05_RS16235 489960..490073 + 114 WP_175247203.1 acetyltransferase -
HPY05_RS16240 490022..490303 + 282 WP_080368113.1 DUF1289 domain-containing protein -
HPY05_RS16245 490603..490860 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HPY05_RS16250 490848..491150 + 303 WP_000229322.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY05_RS16255 491363..491626 + 264 WP_071180065.1 hypothetical protein -
HPY05_RS16260 491947..492129 + 183 WP_080483772.1 DUF645 family protein -
HPY05_RS16265 492327..492875 + 549 WP_053543578.1 hypothetical protein -
HPY05_RS16270 493159..493380 + 222 WP_081017977.1 DUF3709 domain-containing protein -
HPY05_RS16275 493667..494305 + 639 WP_175247204.1 hypothetical protein -
HPY05_RS16280 494592..494774 + 183 WP_033933192.1 DUF645 family protein -
HPY05_RS16285 495077..495187 + 111 WP_080483846.1 DUF645 family protein -
HPY05_RS16290 495209..495244 + 36 WP_108248532.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 317868..527734 209866
- inside Genomic island - - 489105..513383 24278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11737.67 Da        Isoelectric Point: 5.1972

>T158007 WP_000229322.1 NZ_CP053811:490848-491150 [Vibrio cholerae]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T158007 NZ_CP069542:1113914-1114228 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT158007 WP_000861987.1 NZ_CP053811:490603-490860 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT158007 NZ_CP069542:1114225-1114641 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0PYS1

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References