Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-Phd |
| Location | 490603..491150 | Replicon | chromosome |
| Accession | NZ_CP053811 | ||
| Organism | Vibrio cholerae strain W6G | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A0Q0PYS1 |
| Locus tag | HPY05_RS16250 | Protein ID | WP_000229322.1 |
| Coordinates | 490848..491150 (+) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9KM93 |
| Locus tag | HPY05_RS16245 | Protein ID | WP_000861987.1 |
| Coordinates | 490603..490860 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY05_RS16205 | 485674..486177 | + | 504 | WP_001158952.1 | DinB family protein | - |
| HPY05_RS16210 | 486318..487139 | + | 822 | WP_175247201.1 | DUF2806 domain-containing protein | - |
| HPY05_RS16215 | 487289..487792 | + | 504 | WP_139284506.1 | hypothetical protein | - |
| HPY05_RS16220 | 488511..488729 | + | 219 | WP_044128180.1 | DUF3709 domain-containing protein | - |
| HPY05_RS16225 | 489105..489341 | + | 237 | WP_175247202.1 | hypothetical protein | - |
| HPY05_RS16230 | 489665..489844 | + | 180 | WP_175247344.1 | DUF645 family protein | - |
| HPY05_RS16235 | 489960..490073 | + | 114 | WP_175247203.1 | acetyltransferase | - |
| HPY05_RS16240 | 490022..490303 | + | 282 | WP_080368113.1 | DUF1289 domain-containing protein | - |
| HPY05_RS16245 | 490603..490860 | + | 258 | WP_000861987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| HPY05_RS16250 | 490848..491150 | + | 303 | WP_000229322.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HPY05_RS16255 | 491363..491626 | + | 264 | WP_071180065.1 | hypothetical protein | - |
| HPY05_RS16260 | 491947..492129 | + | 183 | WP_080483772.1 | DUF645 family protein | - |
| HPY05_RS16265 | 492327..492875 | + | 549 | WP_053543578.1 | hypothetical protein | - |
| HPY05_RS16270 | 493159..493380 | + | 222 | WP_081017977.1 | DUF3709 domain-containing protein | - |
| HPY05_RS16275 | 493667..494305 | + | 639 | WP_175247204.1 | hypothetical protein | - |
| HPY05_RS16280 | 494592..494774 | + | 183 | WP_033933192.1 | DUF645 family protein | - |
| HPY05_RS16285 | 495077..495187 | + | 111 | WP_080483846.1 | DUF645 family protein | - |
| HPY05_RS16290 | 495209..495244 | + | 36 | WP_108248532.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 317868..527734 | 209866 | |
| - | inside | Genomic island | - | - | 489105..513383 | 24278 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11737.67 Da Isoelectric Point: 5.1972
>T158007 WP_000229322.1 NZ_CP053811:490848-491150 [Vibrio cholerae]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ
Download Length: 303 bp
>T158007 NZ_CP069542:1113914-1114228 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9647.15 Da Isoelectric Point: 7.3178
>AT158007 WP_000861987.1 NZ_CP053811:490603-490860 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
Download Length: 258 bp
>AT158007 NZ_CP069542:1114225-1114641 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0Q0PYS1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1T4SLM9 |