Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 480881..481409 Replicon chromosome
Accession NZ_CP053811
Organism Vibrio cholerae strain W6G

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag HPY05_RS16170 Protein ID WP_000221354.1
Coordinates 481122..481409 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag HPY05_RS16165 Protein ID WP_001250179.1
Coordinates 480881..481132 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY05_RS16130 476973..477125 + 153 WP_161803584.1 DUF3709 domain-containing protein -
HPY05_RS16135 477565..477675 + 111 WP_080483846.1 DUF645 family protein -
HPY05_RS16140 477697..477732 + 36 WP_108248532.1 hypothetical protein -
HPY05_RS16145 478046..478471 + 426 WP_001898445.1 hypothetical protein -
HPY05_RS16150 478615..478977 + 363 WP_175247343.1 DUF4144 domain-containing protein -
HPY05_RS16155 479138..479602 + 465 WP_000392739.1 ASCH domain-containing protein -
HPY05_RS16160 480438..480617 + 180 Protein_536 DUF645 family protein -
HPY05_RS16165 480881..481132 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HPY05_RS16170 481122..481409 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY05_RS16175 481581..482714 + 1134 WP_128739198.1 RelA/SpoT domain-containing protein -
HPY05_RS16180 482918..483307 + 390 WP_000491260.1 VOC family protein -
HPY05_RS16185 483461..483892 + 432 WP_057556420.1 hypothetical protein -
HPY05_RS16190 484038..484427 + 390 WP_055032243.1 hypothetical protein -
HPY05_RS16195 484743..484913 + 171 WP_033929208.1 DUF645 family protein -
HPY05_RS16200 485267..485449 + 183 Protein_544 DUF645 family protein -
HPY05_RS16205 485674..486177 + 504 WP_001158952.1 DinB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 317868..527734 209866


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T158006 WP_000221354.1 NZ_CP053811:481122-481409 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T158006 NZ_CP069542:c1071032-1070568 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT158006 WP_001250179.1 NZ_CP053811:480881-481132 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT158006 NZ_CP069542:c1071367-1071032 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KZS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0X1KZS8

References