158005

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 474450..475009 Replicon chromosome
Accession NZ_CP053811
Organism Vibrio cholerae strain W6G

Toxin (Protein)


Gene name relE Uniprot ID D7HHK2
Locus tag HPY05_RS16110 Protein ID WP_000578471.1
Coordinates 474450..474728 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag HPY05_RS16115 Protein ID WP_000381183.1
Coordinates 474725..475009 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY05_RS16070 469778..469957 + 180 WP_005522103.1 DUF645 family protein -
HPY05_RS16075 470136..470621 + 486 WP_000495105.1 GNAT family N-acetyltransferase -
HPY05_RS16080 470650..471609 - 960 WP_001107099.1 IS30 family transposase -
HPY05_RS16085 471862..472239 + 378 WP_000798825.1 hypothetical protein -
HPY05_RS16090 472393..472857 + 465 WP_000392739.1 ASCH domain-containing protein -
HPY05_RS16095 473135..473371 + 237 WP_071170843.1 DUF3709 domain-containing protein -
HPY05_RS16100 473638..473954 - 317 Protein_524 type II toxin-antitoxin system RelE/ParE family toxin -
HPY05_RS16105 473973..474215 - 243 WP_001961623.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HPY05_RS16110 474450..474728 - 279 WP_000578471.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HPY05_RS16115 474725..475009 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HPY05_RS16120 475243..475479 - 237 WP_000772125.1 RNA-binding protein -
HPY05_RS16125 475778..476101 + 324 WP_001886489.1 DUF3709 domain-containing protein -
HPY05_RS16130 476973..477125 + 153 WP_161803584.1 DUF3709 domain-containing protein -
HPY05_RS16135 477565..477675 + 111 WP_080483846.1 DUF645 family protein -
HPY05_RS16140 477697..477732 + 36 WP_108248532.1 hypothetical protein -
HPY05_RS16145 478046..478471 + 426 WP_001898445.1 hypothetical protein -
HPY05_RS16150 478615..478977 + 363 WP_175247343.1 DUF4144 domain-containing protein -
HPY05_RS16155 479138..479602 + 465 WP_000392739.1 ASCH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 317868..527734 209866


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10838.56 Da        Isoelectric Point: 4.6794

>T158005 WP_000578471.1 NZ_CP053811:c474728-474450 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T158005 NZ_CP069542:619485-619592 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT158005 WP_000381183.1 NZ_CP053811:c475009-474725 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT158005 NZ_CP069542:c619437-619371 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References