Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YafQ-RelB |
| Location | 433598..434138 | Replicon | chromosome |
| Accession | NZ_CP053811 | ||
| Organism | Vibrio cholerae strain W6G | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A151JGK8 |
| Locus tag | HPY05_RS15770 | Protein ID | WP_000277238.1 |
| Coordinates | 433598..433867 (-) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9KML3 |
| Locus tag | HPY05_RS15775 | Protein ID | WP_001258569.1 |
| Coordinates | 433860..434138 (-) | Length | 93 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY05_RS15720 | 428884..429567 | + | 684 | WP_001010781.1 | hypothetical protein | - |
| HPY05_RS15725 | 429706..430479 | + | 774 | WP_175247187.1 | NERD domain-containing protein | - |
| HPY05_RS15730 | 430772..430954 | + | 183 | Protein_450 | DUF645 family protein | - |
| HPY05_RS15735 | 431139..431429 | - | 291 | WP_000221352.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY05_RS15740 | 431419..431667 | - | 249 | WP_000213182.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY05_RS15745 | 431906..432358 | + | 453 | WP_020196891.1 | hypothetical protein | - |
| HPY05_RS15750 | 432355..432465 | + | 111 | WP_175247337.1 | DUF3265 domain-containing protein | - |
| HPY05_RS15755 | 432446..432808 | + | 363 | WP_175247338.1 | DUF4144 domain-containing protein | - |
| HPY05_RS15760 | 432914..433075 | + | 162 | Protein_456 | DUF3709 domain-containing protein | - |
| HPY05_RS15765 | 433096..433329 | + | 234 | WP_142737015.1 | DUF3709 domain-containing protein | - |
| HPY05_RS15770 | 433598..433867 | - | 270 | WP_000277238.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
| HPY05_RS15775 | 433860..434138 | - | 279 | WP_001258569.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| HPY05_RS15780 | 434296..434949 | + | 654 | WP_175247339.1 | hypothetical protein | - |
| HPY05_RS15785 | 435040..435200 | + | 161 | Protein_461 | DUF3709 domain-containing protein | - |
| HPY05_RS15790 | 435221..435454 | + | 234 | WP_175247188.1 | DUF3709 domain-containing protein | - |
| HPY05_RS15795 | 435881..435970 | + | 90 | WP_141239104.1 | DUF645 family protein | - |
| HPY05_RS15800 | 435973..436062 | + | 90 | Protein_464 | DUF645 family protein | - |
| HPY05_RS15805 | 436258..437814 | + | 1557 | WP_175247189.1 | GIY-YIG nuclease family protein | - |
| HPY05_RS15810 | 438010..438870 | + | 861 | WP_175247340.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 317868..527734 | 209866 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10406.11 Da Isoelectric Point: 9.5084
>T158003 WP_000277238.1 NZ_CP053811:c433867-433598 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF
Download Length: 270 bp
>T158003 NZ_CP069540:56021-56350 [Acinetobacter pittii]
ATGTATACAATTGAATATTACAGCGAAGACGTTCAGGATGAGATTCTTACATTACCTGATGGTCTTTTGGCTCGATATTT
TAACTTAACTGACCGTATGGTGATTTACGGCGCAAACTTAGGAGAACCTCACACATTACCAATGAGTAAAGGACTATTTG
AGTTGCGCTTAAAATCTCAAGAAGGTATTGCTCGTGTTATGTATTGCACACTAGTCGGTAAACGCATTGTAATGCTCCAT
AGTTTTGTTAAGAAAACCCAAAAAACACCTAAGCAAGATCTAAACCTAGCACTTGACCGCATGAAAGAGGTGAAAAATGC
GAACACATGA
ATGTATACAATTGAATATTACAGCGAAGACGTTCAGGATGAGATTCTTACATTACCTGATGGTCTTTTGGCTCGATATTT
TAACTTAACTGACCGTATGGTGATTTACGGCGCAAACTTAGGAGAACCTCACACATTACCAATGAGTAAAGGACTATTTG
AGTTGCGCTTAAAATCTCAAGAAGGTATTGCTCGTGTTATGTATTGCACACTAGTCGGTAAACGCATTGTAATGCTCCAT
AGTTTTGTTAAGAAAACCCAAAAAACACCTAAGCAAGATCTAAACCTAGCACTTGACCGCATGAAAGAGGTGAAAAATGC
GAACACATGA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10088.58 Da Isoelectric Point: 6.0728
>AT158003 WP_001258569.1 NZ_CP053811:c434138-433860 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV
Download Length: 279 bp
>AT158003 NZ_CP069540:56337-56624 [Acinetobacter pittii]
ATGCGAACACATGAAGAAATGAAAGCACTTGCATTATCTCGTTCAGCAGTGCGTACCGAATACGAACGAATTGAACGTGA
AGAAATGCCCCTGCTCGATATGGTACTTACTGCACGTCGAGATGCAGGTCTATCCCAAGCGCAAATCGCGGAACGCATGG
GAACAAGTGTACCTGCCGTTTCACGGCTAGAAAAAGCATTGATCACAGGCAAACCATCACCATCTATTGCCACATTGCAA
AAATATGCTGCGGCAATTGGTAAACATGTTGAAGTGCGTTTTGTCTAA
ATGCGAACACATGAAGAAATGAAAGCACTTGCATTATCTCGTTCAGCAGTGCGTACCGAATACGAACGAATTGAACGTGA
AGAAATGCCCCTGCTCGATATGGTACTTACTGCACGTCGAGATGCAGGTCTATCCCAAGCGCAAATCGCGGAACGCATGG
GAACAAGTGTACCTGCCGTTTCACGGCTAGAAAAAGCATTGATCACAGGCAAACCATCACCATCTATTGCCACATTGCAA
AAATATGCTGCGGCAATTGGTAAACATGTTGAAGTGCGTTTTGTCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A151JGK8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A151KTP9 |