Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 433598..434138 Replicon chromosome
Accession NZ_CP053811
Organism Vibrio cholerae strain W6G

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag HPY05_RS15770 Protein ID WP_000277238.1
Coordinates 433598..433867 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag HPY05_RS15775 Protein ID WP_001258569.1
Coordinates 433860..434138 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY05_RS15720 428884..429567 + 684 WP_001010781.1 hypothetical protein -
HPY05_RS15725 429706..430479 + 774 WP_175247187.1 NERD domain-containing protein -
HPY05_RS15730 430772..430954 + 183 Protein_450 DUF645 family protein -
HPY05_RS15735 431139..431429 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY05_RS15740 431419..431667 - 249 WP_000213182.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HPY05_RS15745 431906..432358 + 453 WP_020196891.1 hypothetical protein -
HPY05_RS15750 432355..432465 + 111 WP_175247337.1 DUF3265 domain-containing protein -
HPY05_RS15755 432446..432808 + 363 WP_175247338.1 DUF4144 domain-containing protein -
HPY05_RS15760 432914..433075 + 162 Protein_456 DUF3709 domain-containing protein -
HPY05_RS15765 433096..433329 + 234 WP_142737015.1 DUF3709 domain-containing protein -
HPY05_RS15770 433598..433867 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
HPY05_RS15775 433860..434138 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HPY05_RS15780 434296..434949 + 654 WP_175247339.1 hypothetical protein -
HPY05_RS15785 435040..435200 + 161 Protein_461 DUF3709 domain-containing protein -
HPY05_RS15790 435221..435454 + 234 WP_175247188.1 DUF3709 domain-containing protein -
HPY05_RS15795 435881..435970 + 90 WP_141239104.1 DUF645 family protein -
HPY05_RS15800 435973..436062 + 90 Protein_464 DUF645 family protein -
HPY05_RS15805 436258..437814 + 1557 WP_175247189.1 GIY-YIG nuclease family protein -
HPY05_RS15810 438010..438870 + 861 WP_175247340.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 317868..527734 209866


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T158003 WP_000277238.1 NZ_CP053811:c433867-433598 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T158003 NZ_CP069540:56021-56350 [Acinetobacter pittii]
ATGTATACAATTGAATATTACAGCGAAGACGTTCAGGATGAGATTCTTACATTACCTGATGGTCTTTTGGCTCGATATTT
TAACTTAACTGACCGTATGGTGATTTACGGCGCAAACTTAGGAGAACCTCACACATTACCAATGAGTAAAGGACTATTTG
AGTTGCGCTTAAAATCTCAAGAAGGTATTGCTCGTGTTATGTATTGCACACTAGTCGGTAAACGCATTGTAATGCTCCAT
AGTTTTGTTAAGAAAACCCAAAAAACACCTAAGCAAGATCTAAACCTAGCACTTGACCGCATGAAAGAGGTGAAAAATGC
GAACACATGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT158003 WP_001258569.1 NZ_CP053811:c434138-433860 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT158003 NZ_CP069540:56337-56624 [Acinetobacter pittii]
ATGCGAACACATGAAGAAATGAAAGCACTTGCATTATCTCGTTCAGCAGTGCGTACCGAATACGAACGAATTGAACGTGA
AGAAATGCCCCTGCTCGATATGGTACTTACTGCACGTCGAGATGCAGGTCTATCCCAAGCGCAAATCGCGGAACGCATGG
GAACAAGTGTACCTGCCGTTTCACGGCTAGAAAAAGCATTGATCACAGGCAAACCATCACCATCTATTGCCACATTGCAA
AAATATGCTGCGGCAATTGGTAAACATGTTGAAGTGCGTTTTGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References