Detailed information of TA system TA158001

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 427489..428027
• Replicon: chromosome
• Accession: NZ_CP053811
• Organism: Vibrio cholerae strain W6G

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: HPY05_RS15705
• Protein ID: WP_000802134.1
• Coordinates: 427489..427788 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A271VK51
• Locus tag: HPY05_RS15710
• Protein ID: WP_001107720.1
• Coordinates: 427785..428027 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY05_RS15665	423197..423835	+	639	WP_095472335.1	hypothetical protein	-
HPY05_RS15670	423963..424280	-	318	WP_000077449.1	CcdB family protein	-
HPY05_RS15675	424280..424525	-	246	WP_001260797.1	type II toxin-antitoxin system CcdA family antitoxin	-
HPY05_RS15680	424827..425063	+	237	WP_175247186.1	DUF645 family protein	-
HPY05_RS15685	425262..425753	+	492	WP_005527260.1	hypothetical protein	-
HPY05_RS15690	426227..426337	+	111	WP_072599465.1	DUF3265 domain-containing protein	-
HPY05_RS15695	426370..426903	+	534	WP_069217114.1	GNAT family N-acetyltransferase	-
HPY05_RS15700	427371..427481	+	111	WP_072599357.1	DUF3265 domain-containing protein	-
HPY05_RS15705	427489..427788	-	300	WP_000802134.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY05_RS15710	427785..428027	-	243	WP_001107720.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
HPY05_RS15715	428386..428604	+	219	WP_044128180.1	DUF3709 domain-containing protein	-
HPY05_RS15720	428884..429567	+	684	WP_001010781.1	hypothetical protein	-
HPY05_RS15725	429706..430479	+	774	WP_175247187.1	NERD domain-containing protein	-
HPY05_RS15730	430772..430954	+	183	Protein_450	DUF645 family protein	-
HPY05_RS15735	431139..431429	-	291	WP_000221352.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HPY05_RS15740	431419..431667	-	249	WP_000213182.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
HPY05_RS15745	431906..432358	+	453	WP_020196891.1	hypothetical protein	-
HPY05_RS15750	432355..432465	+	111	WP_175247337.1	DUF3265 domain-containing protein	-
HPY05_RS15755	432446..432808	+	363	WP_175247338.1	DUF4144 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	317868..527734	209866

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Antitoxin ParD (1-79)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11601.34 Da
• Isoelectric Point: 9.9232

>T158001 WP_000802134.1 NZ_CP053811:c427788-427489 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQIGSQQ
IRVIRILHKSMDVNPIFGA

Nucleotide

• Length: 300 bp

>T158001 NZ_CP069540:20960-21253 [Acinetobacter pittii]
ATGACTTATAAGCTTTTACGTAATAAGGACTTCACAGCTGAATGGGAAAAGCTTCCTAGTGCTATAAGAGATCAATTTAA
GAAGAAACTCGCCAAGGTCATAGAGCAGCCACATATTCCCAAGAATATGCTTAGAGGTGATCTCACGGGATGTTATAAAA
TTAAATTACTAAAGACTGGAGTTCGACTGGTCTATCAAGTCAAAGATGATCAGGTAGTTATCTTGCTCATCACCGTTGGG
AAACGAGCTGACAGCATAGTTTATGACGAAGCAAAAAAACGCATTAAAGACTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8950.82 Da
• Isoelectric Point: 4.1677

>AT158001 WP_001107720.1 NZ_CP053811:c428027-427785 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLVEGEQSGDADYDLDSFINELDSENIR

Nucleotide

• Length: 243 bp

>AT158001 NZ_CP069540:20725-20970 [Acinetobacter pittii]
ATGGCTACTGTTAACTTCAGGGTTGATGAAGCCCTTAAAGAAAAATCTTATTCAGTTCTTAGAGAACAAGGTATTGCACC
TACTGAGTTTTTTACAAATGTCCTTGAATACATTGCAGCGACTGGGAAACTCCCTGTACAAAAAGCTTTACTCTCAGAAG
AGGATACCGAGCTATTAGCGATTGTTCGTAAACGTATGAATGATCCTAAAGAAATGTTCGAGGAAATTACTTTAGATGAC
TTATAA

Structures

Antitoxin

• AlphaFold DB: A0A271VK51