Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 427489..428027 | Replicon | chromosome |
| Accession | NZ_CP053811 | ||
| Organism | Vibrio cholerae strain W6G | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | HPY05_RS15705 | Protein ID | WP_000802134.1 |
| Coordinates | 427489..427788 (-) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A271VK51 |
| Locus tag | HPY05_RS15710 | Protein ID | WP_001107720.1 |
| Coordinates | 427785..428027 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY05_RS15665 | 423197..423835 | + | 639 | WP_095472335.1 | hypothetical protein | - |
| HPY05_RS15670 | 423963..424280 | - | 318 | WP_000077449.1 | CcdB family protein | - |
| HPY05_RS15675 | 424280..424525 | - | 246 | WP_001260797.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| HPY05_RS15680 | 424827..425063 | + | 237 | WP_175247186.1 | DUF645 family protein | - |
| HPY05_RS15685 | 425262..425753 | + | 492 | WP_005527260.1 | hypothetical protein | - |
| HPY05_RS15690 | 426227..426337 | + | 111 | WP_072599465.1 | DUF3265 domain-containing protein | - |
| HPY05_RS15695 | 426370..426903 | + | 534 | WP_069217114.1 | GNAT family N-acetyltransferase | - |
| HPY05_RS15700 | 427371..427481 | + | 111 | WP_072599357.1 | DUF3265 domain-containing protein | - |
| HPY05_RS15705 | 427489..427788 | - | 300 | WP_000802134.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HPY05_RS15710 | 427785..428027 | - | 243 | WP_001107720.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| HPY05_RS15715 | 428386..428604 | + | 219 | WP_044128180.1 | DUF3709 domain-containing protein | - |
| HPY05_RS15720 | 428884..429567 | + | 684 | WP_001010781.1 | hypothetical protein | - |
| HPY05_RS15725 | 429706..430479 | + | 774 | WP_175247187.1 | NERD domain-containing protein | - |
| HPY05_RS15730 | 430772..430954 | + | 183 | Protein_450 | DUF645 family protein | - |
| HPY05_RS15735 | 431139..431429 | - | 291 | WP_000221352.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY05_RS15740 | 431419..431667 | - | 249 | WP_000213182.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY05_RS15745 | 431906..432358 | + | 453 | WP_020196891.1 | hypothetical protein | - |
| HPY05_RS15750 | 432355..432465 | + | 111 | WP_175247337.1 | DUF3265 domain-containing protein | - |
| HPY05_RS15755 | 432446..432808 | + | 363 | WP_175247338.1 | DUF4144 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 317868..527734 | 209866 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11601.34 Da Isoelectric Point: 9.9232
>T158001 WP_000802134.1 NZ_CP053811:c427788-427489 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQIGSQQ
IRVIRILHKSMDVNPIFGA
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQIGSQQ
IRVIRILHKSMDVNPIFGA
Download Length: 300 bp
>T158001 NZ_CP069540:20960-21253 [Acinetobacter pittii]
ATGACTTATAAGCTTTTACGTAATAAGGACTTCACAGCTGAATGGGAAAAGCTTCCTAGTGCTATAAGAGATCAATTTAA
GAAGAAACTCGCCAAGGTCATAGAGCAGCCACATATTCCCAAGAATATGCTTAGAGGTGATCTCACGGGATGTTATAAAA
TTAAATTACTAAAGACTGGAGTTCGACTGGTCTATCAAGTCAAAGATGATCAGGTAGTTATCTTGCTCATCACCGTTGGG
AAACGAGCTGACAGCATAGTTTATGACGAAGCAAAAAAACGCATTAAAGACTAA
ATGACTTATAAGCTTTTACGTAATAAGGACTTCACAGCTGAATGGGAAAAGCTTCCTAGTGCTATAAGAGATCAATTTAA
GAAGAAACTCGCCAAGGTCATAGAGCAGCCACATATTCCCAAGAATATGCTTAGAGGTGATCTCACGGGATGTTATAAAA
TTAAATTACTAAAGACTGGAGTTCGACTGGTCTATCAAGTCAAAGATGATCAGGTAGTTATCTTGCTCATCACCGTTGGG
AAACGAGCTGACAGCATAGTTTATGACGAAGCAAAAAAACGCATTAAAGACTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8950.82 Da Isoelectric Point: 4.1677
>AT158001 WP_001107720.1 NZ_CP053811:c428027-427785 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLVEGEQSGDADYDLDSFINELDSENIR
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLVEGEQSGDADYDLDSFINELDSENIR
Download Length: 243 bp
>AT158001 NZ_CP069540:20725-20970 [Acinetobacter pittii]
ATGGCTACTGTTAACTTCAGGGTTGATGAAGCCCTTAAAGAAAAATCTTATTCAGTTCTTAGAGAACAAGGTATTGCACC
TACTGAGTTTTTTACAAATGTCCTTGAATACATTGCAGCGACTGGGAAACTCCCTGTACAAAAAGCTTTACTCTCAGAAG
AGGATACCGAGCTATTAGCGATTGTTCGTAAACGTATGAATGATCCTAAAGAAATGTTCGAGGAAATTACTTTAGATGAC
TTATAA
ATGGCTACTGTTAACTTCAGGGTTGATGAAGCCCTTAAAGAAAAATCTTATTCAGTTCTTAGAGAACAAGGTATTGCACC
TACTGAGTTTTTTACAAATGTCCTTGAATACATTGCAGCGACTGGGAAACTCCCTGTACAAAAAGCTTTACTCTCAGAAG
AGGATACCGAGCTATTAGCGATTGTTCGTAAACGTATGAATGATCCTAAAGAAATGTTCGAGGAAATTACTTTAGATGAC
TTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|