Detailed information of TA system TA158000

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-Phd
• Location: 407139..407717
• Replicon: chromosome
• Accession: NZ_CP053811
• Organism: Vibrio cholerae strain W6G

Toxin (Protein)

• Gene name: parE
• Uniprot ID: O68848
• Locus tag: HPY05_RS15530
• Protein ID: WP_001180243.1
• Coordinates: 407139..407456 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: HPY05_RS15535
• Protein ID: WP_001961623.1
• Coordinates: 407475..407717 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY05_RS15495	402830..403255	+	426	WP_000415750.1	hypothetical protein	-
HPY05_RS15500	403436..403726	-	291	WP_000221352.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HPY05_RS15505	403716..403964	-	249	WP_000213182.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
HPY05_RS15510	404156..404644	+	489	WP_175247181.1	GNAT family N-acetyltransferase	-
HPY05_RS15515	404787..405422	+	636	WP_069648801.1	hypothetical protein	-
HPY05_RS15520	405749..405928	+	180	WP_050547145.1	DUF645 family protein	-
HPY05_RS15525	406762..406943	+	182	Protein_409	DUF645 family protein	-
HPY05_RS15530	407139..407456	-	318	WP_001180243.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY05_RS15535	407475..407717	-	243	WP_001961623.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HPY05_RS15540	408040..408288	+	249	WP_175247182.1	DUF645 family protein	-
HPY05_RS15545	408578..408685	+	108	Protein_413	ggdef family protein	-
HPY05_RS15550	409156..409308	+	153	WP_161803584.1	DUF3709 domain-containing protein	-
HPY05_RS15555	409772..409978	+	207	Protein_415	DUF645 family protein	-
HPY05_RS15560	410190..411194	+	1005	WP_000964931.1	LD-carboxypeptidase	-
HPY05_RS15565	411488..411670	+	183	WP_114763558.1	DUF645 family protein	-
HPY05_RS15570	412025..412207	+	183	Protein_418	DUF645 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	317868..527734	209866

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12158.97 Da
• Isoelectric Point: 9.7495

>T158000 WP_001180243.1 NZ_CP053811:c407456-407139 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Nucleotide

• Length: 318 bp

>T158000 NZ_CP069538:3550-3840 [Acinetobacter pittii]
ATGACACTGACGATTAGGTACAAGAAACAATTTAAAAAAGATTTTAAACGGGTAAGCTCAAACCCAAAGCTTAAGAAAGG
ACTCTTAATTTTGAAGGATCTTATTGATGAGCATTTGGTAAAAACAGGGACTGTTCCAGATGAGTATTTACCTCATCCTT
TGATTGGTGAGTGGAAACCCCATATGGAATGCCATATTTTACCTGATTTATTATTAATTTGGGATGTGGATGAAGATAAT
AATGAGCTAATACTTGCTCGGATTGGATCTCATTCTGAACTTTTTGGATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8931.22 Da
• Isoelectric Point: 5.6630

>AT158000 WP_001961623.1 NZ_CP053811:c407717-407475 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDGGKTVDGATFLNTL

Nucleotide

• Length: 243 bp

>AT158000 NZ_CP069538:3291-3566 [Acinetobacter pittii]
ATGAATACTTTGGCAAAAAAAGATGAGTATGTACGTGCTAGGGTTCCAAATGAATTAAAGGTTCAAGCGGAGCGAATTCT
AAAAGAAGTGGGTTTAAATACTACAGATGCTATTCGCTTATTATTAACGCAAGTAGTAAATCGAGGTGGATTTCCTTTAG
AGTTAAGAACCCCTAACCGTACAACAATTGAGGCTATGAACTCTGTTGCAGAACCTAAAAAATTTAGTTCTGCTCAGGAA
TTGTTTACGGATTTAGAAGATGACACTGACGATTAG

Structures

Toxin

• AlphaFold DB: A0A0K9UJR8