Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 403436..403964 | Replicon | chromosome |
| Accession | NZ_CP053811 | ||
| Organism | Vibrio cholerae strain W6G | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | H9L4R3 |
| Locus tag | HPY05_RS15500 | Protein ID | WP_000221352.1 |
| Coordinates | 403436..403726 (-) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | HPY05_RS15505 | Protein ID | WP_000213182.1 |
| Coordinates | 403716..403964 (-) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY05_RS15460 | 398472..398885 | + | 414 | WP_000049417.1 | VOC family protein | - |
| HPY05_RS15465 | 399541..400749 | + | 1209 | WP_158160342.1 | deoxyguanosinetriphosphate triphosphohydrolase family protein | - |
| HPY05_RS15470 | 400759..400869 | + | 111 | WP_082798410.1 | DUF3265 domain-containing protein | - |
| HPY05_RS15475 | 400932..401216 | + | 285 | WP_000048765.1 | antibiotic biosynthesis monooxygenase | - |
| HPY05_RS15480 | 401646..401768 | + | 123 | WP_082321036.1 | DUF3265 domain-containing protein | - |
| HPY05_RS15485 | 401945..402031 | + | 87 | WP_175247335.1 | DUF645 family protein | - |
| HPY05_RS15490 | 402031..402123 | + | 93 | Protein_402 | DUF645 family protein | - |
| HPY05_RS15495 | 402830..403255 | + | 426 | WP_000415750.1 | hypothetical protein | - |
| HPY05_RS15500 | 403436..403726 | - | 291 | WP_000221352.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HPY05_RS15505 | 403716..403964 | - | 249 | WP_000213182.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| HPY05_RS15510 | 404156..404644 | + | 489 | WP_175247181.1 | GNAT family N-acetyltransferase | - |
| HPY05_RS15515 | 404787..405422 | + | 636 | WP_069648801.1 | hypothetical protein | - |
| HPY05_RS15520 | 405749..405928 | + | 180 | WP_050547145.1 | DUF645 family protein | - |
| HPY05_RS15525 | 406762..406943 | + | 182 | Protein_409 | DUF645 family protein | - |
| HPY05_RS15530 | 407139..407456 | - | 318 | WP_001180243.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY05_RS15535 | 407475..407717 | - | 243 | WP_001961623.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY05_RS15540 | 408040..408288 | + | 249 | WP_175247182.1 | DUF645 family protein | - |
| HPY05_RS15545 | 408578..408685 | + | 108 | Protein_413 | ggdef family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 317868..527734 | 209866 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11247.23 Da Isoelectric Point: 10.4678
>T157999 WP_000221352.1 NZ_CP053811:c403726-403436 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD
Download Length: 291 bp
>T157999 NZ_CP069537:c83406-83017 [Acinetobacter pittii]
TTGATAAAAGAATTAAATTTTGAGCTGAAATATAGCCTTGTCTCGGTAATATTTCAGCTTTTTGTTGGTTTGGGTTTAGC
AATCCTGCTTTATCAATTATTAACACCGATATGGTGGCTATGTGCTGTCATTCTTCTATTTATTGGTTTTATTTTCTTTC
TAAAGCAAGCCCAAATATCTCAAATTGAATATTTAGATCAAAAATTATGGTCGGTTGCATATTTTTCGAAAAAAGAAATT
TACCGCGCGGAAATTACTAAAATAATTGATTATCAGTTATTTGTAGTTATTTATCTTGAAGAAACTCCTACGATCATAGC
TATTGTTTGGTTCGATCAGCTTCCTATTCAGCAGTGGAAAAGATTAAAAGTTTTAGAAAAGCTCTATTAA
TTGATAAAAGAATTAAATTTTGAGCTGAAATATAGCCTTGTCTCGGTAATATTTCAGCTTTTTGTTGGTTTGGGTTTAGC
AATCCTGCTTTATCAATTATTAACACCGATATGGTGGCTATGTGCTGTCATTCTTCTATTTATTGGTTTTATTTTCTTTC
TAAAGCAAGCCCAAATATCTCAAATTGAATATTTAGATCAAAAATTATGGTCGGTTGCATATTTTTCGAAAAAAGAAATT
TACCGCGCGGAAATTACTAAAATAATTGATTATCAGTTATTTGTAGTTATTTATCTTGAAGAAACTCCTACGATCATAGC
TATTGTTTGGTTCGATCAGCTTCCTATTCAGCAGTGGAAAAGATTAAAAGTTTTAGAAAAGCTCTATTAA
Antitoxin
Download Length: 83 a.a. Molecular weight: 8964.31 Da Isoelectric Point: 4.1079
>AT157999 WP_000213182.1 NZ_CP053811:c403964-403716 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPANTYELMMDKLEDLELLAIAKERLSEDSVSVNID
DL
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPANTYELMMDKLEDLELLAIAKERLSEDSVSVNID
DL
Download Length: 249 bp
>AT157999 NZ_CP069537:c83670-83413 [Acinetobacter pittii]
ATGTCTGACGAAATGACCTTGGAAGAACGTAAAGTAATTTATCGAGCACGCCGCGGCTTAAAAGAAATTGACGTCTATTT
TGACCCGTATGTAAAAAACTATTATTTAAAAGCTGATCCAGCAGAAAAAGCATTATTTGCAGAGTTAGTCGATCAAGAAG
ATCCGGATTTATTAGATTGGTTCATGGAAGTTTCTGAACCTCCACGTACTGAGTTACGTGAATTTATTTATAAACTAAAA
CAGTATGTGCATGGCTAA
ATGTCTGACGAAATGACCTTGGAAGAACGTAAAGTAATTTATCGAGCACGCCGCGGCTTAAAAGAAATTGACGTCTATTT
TGACCCGTATGTAAAAAACTATTATTTAAAAGCTGATCCAGCAGAAAAAGCATTATTTGCAGAGTTAGTCGATCAAGAAG
ATCCGGATTTATTAGATTGGTTCATGGAAGTTTCTGAACCTCCACGTACTGAGTTACGTGAATTTATTTATAAACTAAAA
CAGTATGTGCATGGCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|