Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | DhiAT/- |
| Location | 370234..371018 | Replicon | chromosome |
| Accession | NZ_CP053811 | ||
| Organism | Vibrio cholerae strain W6G | ||
Toxin (Protein)
| Gene name | dhiT | Uniprot ID | A0A086SLD6 |
| Locus tag | HPY05_RS15225 | Protein ID | WP_001114075.1 |
| Coordinates | 370234..370503 (+) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | dhiA | Uniprot ID | - |
| Locus tag | HPY05_RS15230 | Protein ID | WP_071186347.1 |
| Coordinates | 370497..371018 (+) | Length | 174 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY05_RS15170 | 366007..366285 | - | 279 | WP_000578471.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
| HPY05_RS15175 | 366282..366566 | - | 285 | WP_000381186.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| HPY05_RS15180 | 366688..366894 | + | 207 | Protein_340 | acetyltransferase | - |
| HPY05_RS15185 | 366919..367065 | + | 147 | WP_001898450.1 | DUF645 family protein | - |
| HPY05_RS15190 | 367454..367636 | + | 183 | WP_114763558.1 | DUF645 family protein | - |
| HPY05_RS15195 | 367842..368306 | + | 465 | WP_071180674.1 | ASCH domain-containing protein | - |
| HPY05_RS15200 | 368371..368463 | + | 93 | WP_175247169.1 | acetyltransferase | - |
| HPY05_RS15205 | 368433..368948 | + | 516 | WP_000090011.1 | hypothetical protein | - |
| HPY05_RS15210 | 369243..369425 | + | 183 | WP_032479935.1 | DUF645 family protein | - |
| HPY05_RS15215 | 369623..370039 | + | 417 | WP_095474030.1 | SMI1/KNR4 family protein | - |
| HPY05_RS15220 | 370017..370151 | + | 135 | WP_080281228.1 | DUF3265 domain-containing protein | - |
| HPY05_RS15225 | 370234..370503 | + | 270 | WP_001114075.1 | DUF4160 domain-containing protein | Toxin |
| HPY05_RS15230 | 370497..371018 | + | 522 | WP_071186347.1 | DUF2442 domain-containing protein | Antitoxin |
| HPY05_RS15235 | 371259..371411 | + | 153 | WP_114774755.1 | DUF645 family protein | - |
| HPY05_RS15240 | 371606..372121 | + | 516 | WP_175247170.1 | GNAT family N-acetyltransferase | - |
| HPY05_RS15245 | 372260..372766 | + | 507 | WP_076025889.1 | GNAT family N-acetyltransferase | - |
| HPY05_RS15250 | 372909..373415 | + | 507 | WP_175247171.1 | GNAT family N-acetyltransferase | - |
| HPY05_RS15255 | 373570..373845 | + | 276 | WP_000436062.1 | hypothetical protein | - |
| HPY05_RS15260 | 373980..374405 | + | 426 | WP_055030564.1 | GNAT family N-acetyltransferase | - |
| HPY05_RS15265 | 374566..374940 | + | 375 | WP_175247172.1 | hypothetical protein | - |
| HPY05_RS15270 | 374979..375140 | + | 162 | WP_175247334.1 | DUF3265 domain-containing protein | - |
| HPY05_RS15275 | 375118..375993 | + | 876 | WP_175247173.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 317868..527734 | 209866 | |
| - | flank | IS/Tn | - | - | 364853..365893 | 1040 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10310.94 Da Isoelectric Point: 6.6303
>T157998 WP_001114075.1 NZ_CP053811:370234-370503 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC
Download Length: 270 bp
>T157998 NZ_CP069534:2766614-2766871 [Corynebacterium glucuronolyticum]
ATGAAATACATCTGGAGTACGCACGCTTGGAACGATTACCTGTACTGGCAGGAGACCGATCGGAAAACCGTTAAGCGAAT
CAATGCGCTGATCAAGGACATCTCTCGCAACGGTAACGACGGTATCGGCAAACCCGAGCCTCTAAAGTACGAGCTCAGCG
GTTACTGGTTGCGCAGAATTACCGACGAACACCGCCTTGTGTACAAGTACACCGATGACGCACTTTGCCTTGCGATGTGC
CGGTATCACTGGATCTGA
ATGAAATACATCTGGAGTACGCACGCTTGGAACGATTACCTGTACTGGCAGGAGACCGATCGGAAAACCGTTAAGCGAAT
CAATGCGCTGATCAAGGACATCTCTCGCAACGGTAACGACGGTATCGGCAAACCCGAGCCTCTAAAGTACGAGCTCAGCG
GTTACTGGTTGCGCAGAATTACCGACGAACACCGCCTTGTGTACAAGTACACCGATGACGCACTTTGCCTTGCGATGTGC
CGGTATCACTGGATCTGA
Antitoxin
Download Length: 174 a.a. Molecular weight: 19394.04 Da Isoelectric Point: 8.3939
>AT157998 WP_071186347.1 NZ_CP053811:370497-371018 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSKIKDFKRFSLTRDGSLNWDGNELSAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSKIKDFKRFSLTRDGSLNWDGNELSAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI
Download Length: 522 bp
>AT157998 NZ_CP069534:2766363-2766617 [Corynebacterium glucuronolyticum]
ATGAAAACGATGTCATATTCCGAATCCAGGGCGCGATACGCCGAGGTCCTGCAATCGGTGGTTGACAACCGCGAGGAAAT
CGTCATCACCCGTAGCGGTCACGAATCTGCCGTTATTCTTTCACTTGATGACTACAACTCTCTGCGAGAAACCGCTTACC
TTATGCGTTCGCCACGAAATGCCCAGCTCCTCTTTGAAGCGGTCACGGAGTTGGAATCTGGCAATGGCACCGCAAGAGAT
CTGCTTCCGGAATGA
ATGAAAACGATGTCATATTCCGAATCCAGGGCGCGATACGCCGAGGTCCTGCAATCGGTGGTTGACAACCGCGAGGAAAT
CGTCATCACCCGTAGCGGTCACGAATCTGCCGTTATTCTTTCACTTGATGACTACAACTCTCTGCGAGAAACCGCTTACC
TTATGCGTTCGCCACGAAATGCCCAGCTCCTCTTTGAAGCGGTCACGGAGTTGGAATCTGGCAATGGCACCGCAAGAGAT
CTGCTTCCGGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|