157996

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2215238..2217063 Replicon chromosome
Accession NZ_CP053810
Organism Vibrio cholerae strain W6G

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HPY05_RS09995 Protein ID WP_142993673.1
Coordinates 2215238..2216599 (+) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HPY05_RS10000 Protein ID WP_000804846.1
Coordinates 2216596..2217063 (+) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY05_RS09965 2210773..2212437 + 1665 WP_175246987.1 DNA repair protein RecN -
HPY05_RS09970 2212596..2212955 + 360 WP_001160907.1 outer membrane protein assembly factor BamE -
HPY05_RS09975 2213031..2213336 - 306 WP_001918351.1 RnfH family protein -
HPY05_RS09980 2213339..2213773 - 435 WP_000815880.1 type II toxin-antitoxin system RatA family toxin -
HPY05_RS09985 2213957..2214442 + 486 WP_000162689.1 SsrA-binding protein SmpB -
HPY05_RS09995 2215238..2216599 + 1362 WP_142993673.1 type II toxin-antitoxin system HipA family toxin Toxin
HPY05_RS10000 2216596..2217063 + 468 WP_000804846.1 helix-turn-helix domain-containing protein Antitoxin
HPY05_RS10005 2217655..2219688 + 2034 WP_095461558.1 DNA phosphorothioation-associated putative methyltransferase -
HPY05_RS10010 2219685..2220488 - 804 WP_071180710.1 restriction endonuclease -
HPY05_RS10015 2220495..2221619 - 1125 WP_000214766.1 cysteine desulfurase DndA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-385)

Antitoxin

Cro/C1-type helix-turn-helix domain

(80-138)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51331.23 Da        Isoelectric Point: 4.8586

>T157996 WP_142993673.1 NZ_CP053810:2215238-2216599 [Vibrio cholerae]
MEELTVQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHYDKDDFHAVSLNHPVSFIFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIDQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIYDFAPMKADPEGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEMLLKELAITASKCVGLKQRLALRGVPEQILEMPAVGLNYLSEKLTKWGLL

Download         Length: 1362 bp

>T157996 NZ_CP069531:c9496-9335 [Escherichia coli]
ATGAAACTACCGGGAAATGCCCTTATCTGGTGCGTATTAATCGTGTGCTGCACGTTGTTGATATTCACACTCCTGACCCG
GAATCGTCTGTGCGAAGTCCGGCTGAAGGACGGATACAGGGAAGTTACGGCAACAATGGCTTACGAATCCGGCGGTAAGT
AG

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17047.52 Da        Isoelectric Point: 10.7084

>AT157996 WP_000804846.1 NZ_CP053810:2216596-2217063 [Vibrio cholerae]
MKPSNKESVQDTVARLRANRNQQQPKVGKNATHSSKEQTPLDTPTRSKASKNAKAVSAAERKTEANKIIKHLLLGELTQG
QALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFSLKIGLLPSSPDALKSLLMDGEDG

Download         Length: 468 bp

>AT157996 NZ_CP069531:c9759-9542 [Escherichia coli]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGGAAAGTGAGTGTGGTCAGTGCGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTCGTGTGGCAGAAGGA
CAAAAGCCCCGTAGTTAATTTTTCATTAACCCACGAGGCCTCTGCATGTCTAGTCCAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References