157995

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 1148135..1148898 Replicon chromosome
Accession NZ_CP053810
Organism Vibrio cholerae strain W6G

Toxin (Protein)


Gene name ataT Uniprot ID A0A5B0H076
Locus tag HPY05_RS05400 Protein ID WP_032475876.1
Coordinates 1148135..1148641 (-) Length 169 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A2K9A963
Locus tag HPY05_RS05405 Protein ID WP_001963895.1
Coordinates 1148632..1148898 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY05_RS05360 1143247..1143525 - 279 WP_000058216.1 helix-turn-helix domain-containing protein -
HPY05_RS05365 1143522..1143845 - 324 WP_001896384.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY05_RS05370 1144026..1144307 + 282 WP_000433891.1 type IV conjugative transfer system protein TraL -
HPY05_RS05375 1144304..1144930 + 627 WP_001896361.1 sex pilus assembly -
HPY05_RS05380 1144914..1145811 + 898 Protein_1029 type-F conjugative transfer system secretin TraK -
HPY05_RS05385 1145814..1147064 + 1251 WP_149519259.1 TraB/VirB10 family protein -
HPY05_RS05390 1147139..1147711 + 573 WP_142610872.1 TraV family lipoprotein -
HPY05_RS05395 1147708..1148094 + 387 WP_023584042.1 hypothetical protein -
HPY05_RS05400 1148135..1148641 - 507 WP_032475876.1 GNAT family N-acetyltransferase Toxin
HPY05_RS05405 1148632..1148898 - 267 WP_001963895.1 DUF1778 domain-containing protein Antitoxin
HPY05_RS05410 1149267..1149959 + 693 WP_175246836.1 DsbC family protein -
HPY05_RS05415 1149959..1152358 + 2400 WP_024008831.1 type IV secretion system protein TraC -
HPY05_RS05420 1152351..1152698 + 348 WP_152118583.1 plasmid-related protein -
HPY05_RS05425 1152682..1153194 + 513 WP_175246837.1 S26 family signal peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1128250..1229894 101644


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-146)

Antitoxin

Vibrio phage ICP1, Orf50

(8-83)


Sequences

Toxin        


Download         Length: 169 a.a.        Molecular weight: 18277.02 Da        Isoelectric Point: 7.7717

>T157995 WP_032475876.1 NZ_CP053810:c1148641-1148135 [Vibrio cholerae]
MGISAPTLLTDEHQLNAFQCGIEELNTWLRKQALKSQKRGTARVYVVNDTDAHQVVGYYAIAMGSVSREQAFSSLRRNSP
DPIPMVILARLGVDNAYQGQGIAAGLLKDCIIRSVQAMNAVGGAGILVHAIDGSAQTFYKKFGFKESTFDPLVLMARICD
IEKSLSID

Download         Length: 507 bp

>T157995 NZ_CP069530:c75722-75558 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAATACATTGCGGAGCAGAACCTGAT
AGCAGCCATTGAACTGGACGAACGGATTGGTTATTTCGGACGAACGCACCGGCTTACGCCGGTTTTACATCTGTACTACA
TGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9969.47 Da        Isoelectric Point: 5.8580

>AT157995 WP_001963895.1 NZ_CP053810:c1148898-1148632 [Vibrio cholerae]
MATKTAPINMRVLPSVRDIIDAAASLKKVDRTVFIQQAALNEAHNVLAEQRDFVLEAKAFEAFDNELRAEPQTLEGMKDL
FKRKAPWE

Download         Length: 267 bp

>AT157995 NZ_CP069530:c75988-75719 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGTCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCACGGCGATGTACTTCCCCATGACATGGTCGAATCCTCTGCTGCAGCATGGCGAGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5B0H076

Antitoxin

Source ID Structure
AlphaFold DB A0A2K9A963

References