Detailed information of TA system TA157991

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 508981..509509
• Replicon: chromosome
• Accession: NZ_CP053809
• Organism: Vibrio cholerae strain SP7G

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0X1KZS6
• Locus tag: HPY08_RS15740
• Protein ID: WP_000221354.1
• Coordinates: 509222..509509 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HPY08_RS15735
• Protein ID: WP_001250180.1
• Coordinates: 508981..509232 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY08_RS15700	504397..505842	+	1446	WP_175242904.1	caspase family protein	-
HPY08_RS15705	506141..506294	+	154	Protein_555	DUF645 family protein	-
HPY08_RS15710	506648..506737	+	90	WP_175242905.1	DUF645 family protein	-
HPY08_RS15715	506734..506787	+	54	WP_175243022.1	DUF645 family protein	-
HPY08_RS15720	507024..507341	-	318	WP_001180243.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HPY08_RS15725	507360..507602	-	243	WP_001961623.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
HPY08_RS15730	507720..508679	-	960	WP_001107099.1	IS30 family transposase	-
HPY08_RS15735	508981..509232	+	252	WP_001250180.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HPY08_RS15740	509222..509509	+	288	WP_000221354.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY08_RS15745	509653..510189	+	537	WP_005526589.1	nucleotidyltransferase family protein	-
HPY08_RS15750	510212..511171	-	960	WP_001107099.1	IS30 family transposase	-
HPY08_RS15755	511631..511741	+	111	Protein_565	DUF645 family protein	-
HPY08_RS15760	511983..512396	+	414	WP_000049417.1	VOC family protein	-
HPY08_RS15765	512561..512920	+	360	WP_019830329.1	VOC family protein	-
HPY08_RS15770	513114..513827	+	714	WP_000123660.1	Fic family protein	-
HPY08_RS15775	514189..514299	+	111	Protein_569	DUF645 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	338606..521339	182733
	-	inside	Integron	-	-	339770..520450	180680

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (11-70)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10991.96 Da
• Isoelectric Point: 10.4934

>T157991 WP_000221354.1 NZ_CP053809:509222-509509 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Nucleotide

• Length: 288 bp

>T157991 NZ_CP069529:c29862-29704 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9152.29 Da
• Isoelectric Point: 4.0197

>AT157991 WP_001250180.1 NZ_CP053809:508981-509232 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLSQAVEVNI
DDL

Nucleotide

• Length: 252 bp

>AT157991 NZ_CP069529:c30130-29906 [Escherichia coli]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGGATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Structures

Toxin

• AlphaFold DB: A0A0X1KZS6