Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-Phd |
| Location | 507024..507602 | Replicon | chromosome |
| Accession | NZ_CP053809 | ||
| Organism | Vibrio cholerae strain SP7G | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | O68848 |
| Locus tag | HPY08_RS15720 | Protein ID | WP_001180243.1 |
| Coordinates | 507024..507341 (-) | Length | 106 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | - |
| Locus tag | HPY08_RS15725 | Protein ID | WP_001961623.1 |
| Coordinates | 507360..507602 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY08_RS15680 | 502317..502679 | + | 363 | WP_046122431.1 | DUF4144 domain-containing protein | - |
| HPY08_RS15685 | 503080..503169 | + | 90 | Protein_551 | DUF645 family protein | - |
| HPY08_RS15690 | 503702..503812 | + | 111 | WP_076008659.1 | DUF3265 domain-containing protein | - |
| HPY08_RS15695 | 503851..504237 | + | 387 | WP_001015868.1 | NUDIX hydrolase | - |
| HPY08_RS15700 | 504397..505842 | + | 1446 | WP_175242904.1 | caspase family protein | - |
| HPY08_RS15705 | 506141..506294 | + | 154 | Protein_555 | DUF645 family protein | - |
| HPY08_RS15710 | 506648..506737 | + | 90 | WP_175242905.1 | DUF645 family protein | - |
| HPY08_RS15715 | 506734..506787 | + | 54 | WP_175243022.1 | DUF645 family protein | - |
| HPY08_RS15720 | 507024..507341 | - | 318 | WP_001180243.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HPY08_RS15725 | 507360..507602 | - | 243 | WP_001961623.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| HPY08_RS15730 | 507720..508679 | - | 960 | WP_001107099.1 | IS30 family transposase | - |
| HPY08_RS15735 | 508981..509232 | + | 252 | WP_001250180.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY08_RS15740 | 509222..509509 | + | 288 | WP_000221354.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY08_RS15745 | 509653..510189 | + | 537 | WP_005526589.1 | nucleotidyltransferase family protein | - |
| HPY08_RS15750 | 510212..511171 | - | 960 | WP_001107099.1 | IS30 family transposase | - |
| HPY08_RS15755 | 511631..511741 | + | 111 | Protein_565 | DUF645 family protein | - |
| HPY08_RS15760 | 511983..512396 | + | 414 | WP_000049417.1 | VOC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 338606..521339 | 182733 | |
| - | inside | Integron | - | - | 339770..520450 | 180680 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12158.97 Da Isoelectric Point: 9.7495
>T157990 WP_001180243.1 NZ_CP053809:c507341-507024 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
Download Length: 318 bp
>T157990 NZ_CP069528:c5173431-5173054 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCAGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCAGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8931.22 Da Isoelectric Point: 5.6630
>AT157990 WP_001961623.1 NZ_CP053809:c507602-507360 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDGGKTVDGATFLNTL
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDGGKTVDGATFLNTL
Download Length: 243 bp
>AT157990 NZ_CP069528:c5173888-5173520 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGTACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACCGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGTACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACCGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|