Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 501648..502213 | Replicon | chromosome |
| Accession | NZ_CP053809 | ||
| Organism | Vibrio cholerae strain SP7G | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D7HCW8 |
| Locus tag | HPY08_RS15675 | Protein ID | WP_000869999.1 |
| Coordinates | 501926..502213 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | D0IIK3 |
| Locus tag | HPY08_RS15670 | Protein ID | WP_000086649.1 |
| Coordinates | 501648..501929 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY08_RS15625 | 496928..497227 | - | 300 | WP_000802131.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY08_RS15630 | 497224..497466 | - | 243 | WP_002044787.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| HPY08_RS15635 | 497514..497645 | + | 132 | WP_080483479.1 | DUF3265 domain-containing protein | - |
| HPY08_RS15640 | 497832..498011 | + | 180 | WP_095457894.1 | DUF645 family protein | - |
| HPY08_RS15645 | 498235..498975 | + | 741 | WP_175243021.1 | PhzF family phenazine biosynthesis protein | - |
| HPY08_RS15650 | 499119..499607 | + | 489 | WP_069648819.1 | hypothetical protein | - |
| HPY08_RS15655 | 499630..500589 | - | 960 | WP_001107099.1 | IS30 family transposase | - |
| HPY08_RS15660 | 500831..501439 | + | 609 | WP_000529841.1 | pyridoxamine 5'-phosphate oxidase family protein | - |
| HPY08_RS15665 | 501447..501557 | + | 111 | WP_080008060.1 | DUF3265 domain-containing protein | - |
| HPY08_RS15670 | 501648..501929 | + | 282 | WP_000086649.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| HPY08_RS15675 | 501926..502213 | + | 288 | WP_000869999.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HPY08_RS15680 | 502317..502679 | + | 363 | WP_046122431.1 | DUF4144 domain-containing protein | - |
| HPY08_RS15685 | 503080..503169 | + | 90 | Protein_551 | DUF645 family protein | - |
| HPY08_RS15690 | 503702..503812 | + | 111 | WP_076008659.1 | DUF3265 domain-containing protein | - |
| HPY08_RS15695 | 503851..504237 | + | 387 | WP_001015868.1 | NUDIX hydrolase | - |
| HPY08_RS15700 | 504397..505842 | + | 1446 | WP_175242904.1 | caspase family protein | - |
| HPY08_RS15705 | 506141..506294 | + | 154 | Protein_555 | DUF645 family protein | - |
| HPY08_RS15710 | 506648..506737 | + | 90 | WP_175242905.1 | DUF645 family protein | - |
| HPY08_RS15715 | 506734..506787 | + | 54 | WP_175243022.1 | DUF645 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 338606..521339 | 182733 | |
| - | inside | Integron | - | - | 339770..520450 | 180680 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10997.74 Da Isoelectric Point: 6.0710
>T157989 WP_000869999.1 NZ_CP053809:501926-502213 [Vibrio cholerae]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV
Download Length: 288 bp
>T157989 NZ_CP069528:c4944687-4944223 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGCGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGCGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10361.93 Da Isoelectric Point: 5.1548
>AT157989 WP_000086649.1 NZ_CP053809:501648-501929 [Vibrio cholerae]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK
Download Length: 282 bp
>AT157989 NZ_CP069528:c4945022-4944687 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCTGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCTGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3AEF1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K9UIW4 |