Detailed information of TA system TA157988

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 496928..497466
• Replicon: chromosome
• Accession: NZ_CP053809
• Organism: Vibrio cholerae strain SP7G

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A0N8UHD2
• Locus tag: HPY08_RS15625
• Protein ID: WP_000802131.1
• Coordinates: 496928..497227 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A0Q0JMN6
• Locus tag: HPY08_RS15630
• Protein ID: WP_002044787.1
• Coordinates: 497224..497466 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY08_RS15585	492354..492590	+	237	WP_162805884.1	DUF645 family protein	-
HPY08_RS15590	492795..493646	+	852	WP_000446947.1	hypothetical protein	-
HPY08_RS15595	493734..494396	+	663	WP_000084910.1	Vat family streptogramin A O-acetyltransferase	-
HPY08_RS15600	494748..494843	+	96	WP_001907607.1	DUF645 family protein	-
HPY08_RS15605	495041..495526	+	486	WP_175242902.1	GNAT family N-acetyltransferase	-
HPY08_RS15610	495511..495633	+	123	WP_175242903.1	DUF3265 domain-containing protein	-
HPY08_RS15615	495820..495969	+	150	Protein_537	DUF645 family protein	-
HPY08_RS15620	496169..496804	+	636	WP_095474051.1	hypothetical protein	-
HPY08_RS15625	496928..497227	-	300	WP_000802131.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY08_RS15630	497224..497466	-	243	WP_002044787.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
HPY08_RS15635	497514..497645	+	132	WP_080483479.1	DUF3265 domain-containing protein	-
HPY08_RS15640	497832..498011	+	180	WP_095457894.1	DUF645 family protein	-
HPY08_RS15645	498235..498975	+	741	WP_175243021.1	PhzF family phenazine biosynthesis protein	-
HPY08_RS15650	499119..499607	+	489	WP_069648819.1	hypothetical protein	-
HPY08_RS15655	499630..500589	-	960	WP_001107099.1	IS30 family transposase	-
HPY08_RS15660	500831..501439	+	609	WP_000529841.1	pyridoxamine 5'-phosphate oxidase family protein	-
HPY08_RS15665	501447..501557	+	111	WP_080008060.1	DUF3265 domain-containing protein	-
HPY08_RS15670	501648..501929	+	282	WP_000086649.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
HPY08_RS15675	501926..502213	+	288	WP_000869999.1	type II toxin-antitoxin system RelE/ParE family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	338606..521339	182733
	-	inside	Integron	-	-	339770..520450	180680

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Antitoxin ParD (1-78)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11607.26 Da
• Isoelectric Point: 9.9232

>T157988 WP_000802131.1 NZ_CP053809:c497227-496928 [Vibrio cholerae]
MKPFNLTTAAKTDLRDIALFTQRRWGKEQRNIYLKQFDDSFWLLAENPDIGKSCDEIRDGYRKFPQGSHVIFYQQTGSQQ
IRVVRILHKSMDVNPIFGA

Nucleotide

• Length: 300 bp

>T157988 NZ_CP069528:4524544-4524651 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8979.81 Da
• Isoelectric Point: 4.1677

>AT157988 WP_002044787.1 NZ_CP053809:c497466-497224 [Vibrio cholerae]
MAKNTSITLGEHFDGFITNQIQSGRYGSASEVIRSALRLLENQETKLQTLRQLLVEGEQSGDADYDLDSFINELDSETNR

Nucleotide

• Length: 243 bp

>AT157988 NZ_CP069528:c4524495-4524429 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATATTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A0N8UHD2

Antitoxin

• AlphaFold DB: A0A0Q0JMN6