Detailed information of TA system TA157987

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 489767..490307
• Replicon: chromosome
• Accession: NZ_CP053809
• Organism: Vibrio cholerae strain SP7G

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HPY08_RS15565
• Protein ID: WP_000549239.1
• Coordinates: 489767..490036 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D7HHI1
• Locus tag: HPY08_RS15570
• Protein ID: WP_001258568.1
• Coordinates: 490029..490307 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY08_RS15530	485211..485615	+	405	WP_175242899.1	DUF1801 domain-containing protein	-
HPY08_RS15535	485768..486403	+	636	WP_000691786.1	DUF2807 domain-containing protein	-
HPY08_RS15540	486560..486946	+	387	WP_001898256.1	MmcQ/YjbR family DNA-binding protein	-
HPY08_RS15545	486969..487928	-	960	WP_001107099.1	IS30 family transposase	-
HPY08_RS15550	488165..488563	+	399	WP_044128234.1	fosfomycin resistance glutathione transferase	-
HPY08_RS15555	488744..488980	-	237	WP_175242900.1	RNA-binding protein	-
HPY08_RS15560	489396..489570	+	175	Protein_526	DUF645 family protein	-
HPY08_RS15565	489767..490036	-	270	WP_000549239.1	type II toxin-antitoxin system YafQ family toxin	Toxin
HPY08_RS15570	490029..490307	-	279	WP_001258568.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HPY08_RS15575	490986..491390	+	405	WP_175242901.1	DUF1801 domain-containing protein	-
HPY08_RS15580	491541..492101	+	561	WP_114763342.1	hypothetical protein	-
HPY08_RS15585	492354..492590	+	237	WP_162805884.1	DUF645 family protein	-
HPY08_RS15590	492795..493646	+	852	WP_000446947.1	hypothetical protein	-
HPY08_RS15595	493734..494396	+	663	WP_000084910.1	Vat family streptogramin A O-acetyltransferase	-
HPY08_RS15600	494748..494843	+	96	WP_001907607.1	DUF645 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	338606..521339	182733
	-	inside	Integron	-	-	339770..520450	180680

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-84)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10380.08 Da
• Isoelectric Point: 9.6024

>T157987 WP_000549239.1 NZ_CP053809:c490036-489767 [Vibrio cholerae]
MHKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Nucleotide

• Length: 270 bp

>T157987 NZ_CP069528:c4107893-4107582 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10060.53 Da
• Isoelectric Point: 6.0728

>AT157987 WP_001258568.1 NZ_CP053809:c490307-490029 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHA

Nucleotide

• Length: 279 bp

>AT157987 NZ_CP069528:c4107581-4107291 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGTACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Structures

Antitoxin

• AlphaFold DB: D7HHI1