Detailed information of TA system TA157986

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 473581..474140
• Replicon: chromosome
• Accession: NZ_CP053809
• Organism: Vibrio cholerae strain SP7G

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HPY08_RS15450
• Protein ID: WP_114717222.1
• Coordinates: 473581..473859 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HPY08_RS15455
• Protein ID: WP_000381186.1
• Coordinates: 473856..474140 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY08_RS15415	468903..469862	-	960	WP_001107099.1	IS30 family transposase	-
HPY08_RS15420	470104..470601	+	498	WP_000259910.1	GNAT family N-acetyltransferase	-
HPY08_RS15425	470783..471106	+	324	WP_080299109.1	DUF3709 domain-containing protein	-
HPY08_RS15430	471377..471874	+	498	WP_175242894.1	DUF2867 domain-containing protein	-
HPY08_RS15435	471930..472025	+	96	WP_175242895.1	acetyltransferase	-
HPY08_RS15440	472009..472851	+	843	WP_114717245.1	hypothetical protein	-
HPY08_RS15445	472986..473441	+	456	WP_114717223.1	hypothetical protein	-
HPY08_RS15450	473581..473859	-	279	WP_114717222.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY08_RS15455	473856..474140	-	285	WP_000381186.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HPY08_RS15460	474319..474834	+	516	WP_076025898.1	MazG-related protein	-
HPY08_RS15465	475678..475995	+	318	WP_142578524.1	hypothetical protein	-
HPY08_RS15470	476250..476675	+	426	WP_175242896.1	hypothetical protein	-
HPY08_RS15475	476848..477261	+	414	WP_019829643.1	GNAT family N-acetyltransferase	-
HPY08_RS15480	477437..478036	+	600	WP_001898552.1	porin family protein	-
HPY08_RS15485	478195..478659	+	465	WP_175242838.1	N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	338606..521339	182733
	-	inside	Integron	-	-	339770..520450	180680

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-70)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10852.59 Da
• Isoelectric Point: 4.6794

>T157986 WP_114717222.1 NZ_CP053809:c473859-473581 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIEAKVENLLEQPLMGLQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Nucleotide

• Length: 279 bp

>T157986 NZ_CP069528:c3775065-3774892 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTTCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10915.28 Da
• Isoelectric Point: 8.0775

>AT157986 WP_000381186.1 NZ_CP053809:c474140-473856 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFVEHDIAKVR
MAERKAKIRNRGHA

Nucleotide

• Length: 285 bp

>AT157986 NZ_CP069528:c3775389-3775093 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG