Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 463216..463744 | Replicon | chromosome |
| Accession | NZ_CP053809 | ||
| Organism | Vibrio cholerae strain SP7G | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | HPY08_RS15355 | Protein ID | WP_108336305.1 |
| Coordinates | 463216..463506 (-) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | H9L4T4 |
| Locus tag | HPY08_RS15360 | Protein ID | WP_000213183.1 |
| Coordinates | 463496..463744 (-) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY08_RS15315 | 458422..458679 | + | 258 | WP_000861987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY08_RS15320 | 458667..458969 | + | 303 | WP_000229320.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY08_RS15325 | 459130..459663 | + | 534 | WP_000679868.1 | GNAT family N-acetyltransferase | - |
| HPY08_RS15330 | 459813..460268 | + | 456 | WP_000432865.1 | hypothetical protein | - |
| HPY08_RS15335 | 460564..460746 | + | 183 | WP_000923330.1 | DUF645 family protein | - |
| HPY08_RS15340 | 460952..461233 | + | 282 | WP_000382665.1 | hypothetical protein | - |
| HPY08_RS15345 | 461306..461770 | - | 465 | WP_055065351.1 | hypothetical protein | - |
| HPY08_RS15350 | 462838..463029 | - | 192 | WP_114717204.1 | hypothetical protein | - |
| HPY08_RS15355 | 463216..463506 | - | 291 | WP_108336305.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HPY08_RS15360 | 463496..463744 | - | 249 | WP_000213183.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| HPY08_RS15365 | 463973..464476 | + | 504 | WP_001160994.1 | DinB family protein | - |
| HPY08_RS15370 | 464624..464899 | + | 276 | WP_000436062.1 | hypothetical protein | - |
| HPY08_RS15375 | 465193..465399 | + | 207 | WP_175242892.1 | DUF645 family protein | - |
| HPY08_RS15380 | 465574..466009 | + | 436 | Protein_490 | GNAT family N-acetyltransferase | - |
| HPY08_RS15385 | 466202..466459 | + | 258 | WP_175242893.1 | hypothetical protein | - |
| HPY08_RS15390 | 466643..467056 | + | 414 | WP_055064865.1 | NUDIX domain-containing protein | - |
| HPY08_RS15395 | 467195..467611 | + | 417 | WP_114717105.1 | DUF1311 domain-containing protein | - |
| HPY08_RS15400 | 467748..468065 | - | 318 | WP_095474062.1 | CcdB family protein | - |
| HPY08_RS15405 | 468065..468310 | - | 246 | WP_001260801.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 338606..521339 | 182733 | |
| - | inside | Integron | - | - | 339770..520450 | 180680 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11247.27 Da Isoelectric Point: 10.5349
>T157985 WP_108336305.1 NZ_CP053809:c463506-463216 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLKQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD
MTYKLEFKKSALKEWKKLAVPLKQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD
Download Length: 291 bp
>T157985 NZ_CP069528:3677564-3677941 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 8937.28 Da Isoelectric Point: 4.1079
>AT157985 WP_000213183.1 NZ_CP053809:c463744-463496 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL
Download Length: 249 bp
>AT157985 NZ_CP069528:3677107-3677487 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGGGGCCGGT
TCAACAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG
GTGTCAGACACACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGGGGCCGGT
TCAACAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|