Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 458422..458969 Replicon chromosome
Accession NZ_CP053809
Organism Vibrio cholerae strain SP7G

Toxin (Protein)


Gene name relE Uniprot ID D7HHP0
Locus tag HPY08_RS15320 Protein ID WP_000229320.1
Coordinates 458667..458969 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag HPY08_RS15315 Protein ID WP_000861987.1
Coordinates 458422..458679 (+) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY08_RS15275 454028..454351 + 324 WP_080299109.1 DUF3709 domain-containing protein -
HPY08_RS15280 454784..455173 + 390 WP_000491261.1 VOC family protein -
HPY08_RS15285 455328..455825 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
HPY08_RS15290 455822..456094 - 273 WP_001915058.1 DUF1778 domain-containing protein -
HPY08_RS15295 456430..456666 + 237 WP_002051081.1 DUF645 family protein -
HPY08_RS15300 456870..457367 - 498 WP_175242890.1 GNAT family N-acetyltransferase -
HPY08_RS15305 457364..457636 - 273 WP_175242891.1 DUF1778 domain-containing protein -
HPY08_RS15310 457875..458213 + 339 WP_046127316.1 hypothetical protein -
HPY08_RS15315 458422..458679 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HPY08_RS15320 458667..458969 + 303 WP_000229320.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY08_RS15325 459130..459663 + 534 WP_000679868.1 GNAT family N-acetyltransferase -
HPY08_RS15330 459813..460268 + 456 WP_000432865.1 hypothetical protein -
HPY08_RS15335 460564..460746 + 183 WP_000923330.1 DUF645 family protein -
HPY08_RS15340 460952..461233 + 282 WP_000382665.1 hypothetical protein -
HPY08_RS15345 461306..461770 - 465 WP_055065351.1 hypothetical protein -
HPY08_RS15350 462838..463029 - 192 WP_114717204.1 hypothetical protein -
HPY08_RS15355 463216..463506 - 291 WP_108336305.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY08_RS15360 463496..463744 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 338606..521339 182733
- inside Integron - - 339770..520450 180680


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 101 a.a.        Molecular weight: 11682.58 Da        Isoelectric Point: 4.8838

>T157984 WP_000229320.1 NZ_CP053809:458667-458969 [Vibrio cholerae]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDAKI
SILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T157984 NZ_CP069528:3474970-3475227 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT157984 WP_000861987.1 NZ_CP053809:458422-458679 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT157984 NZ_CP069528:3475239-3475784 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCGGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB D7HHP0


Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References