Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-Phd |
Location | 458422..458969 | Replicon | chromosome |
Accession | NZ_CP053809 | ||
Organism | Vibrio cholerae strain SP7G |
Toxin (Protein)
Gene name | relE | Uniprot ID | D7HHP0 |
Locus tag | HPY08_RS15320 | Protein ID | WP_000229320.1 |
Coordinates | 458667..458969 (+) | Length | 101 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | Q9KM93 |
Locus tag | HPY08_RS15315 | Protein ID | WP_000861987.1 |
Coordinates | 458422..458679 (+) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HPY08_RS15275 | 454028..454351 | + | 324 | WP_080299109.1 | DUF3709 domain-containing protein | - |
HPY08_RS15280 | 454784..455173 | + | 390 | WP_000491261.1 | VOC family protein | - |
HPY08_RS15285 | 455328..455825 | - | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
HPY08_RS15290 | 455822..456094 | - | 273 | WP_001915058.1 | DUF1778 domain-containing protein | - |
HPY08_RS15295 | 456430..456666 | + | 237 | WP_002051081.1 | DUF645 family protein | - |
HPY08_RS15300 | 456870..457367 | - | 498 | WP_175242890.1 | GNAT family N-acetyltransferase | - |
HPY08_RS15305 | 457364..457636 | - | 273 | WP_175242891.1 | DUF1778 domain-containing protein | - |
HPY08_RS15310 | 457875..458213 | + | 339 | WP_046127316.1 | hypothetical protein | - |
HPY08_RS15315 | 458422..458679 | + | 258 | WP_000861987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
HPY08_RS15320 | 458667..458969 | + | 303 | WP_000229320.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
HPY08_RS15325 | 459130..459663 | + | 534 | WP_000679868.1 | GNAT family N-acetyltransferase | - |
HPY08_RS15330 | 459813..460268 | + | 456 | WP_000432865.1 | hypothetical protein | - |
HPY08_RS15335 | 460564..460746 | + | 183 | WP_000923330.1 | DUF645 family protein | - |
HPY08_RS15340 | 460952..461233 | + | 282 | WP_000382665.1 | hypothetical protein | - |
HPY08_RS15345 | 461306..461770 | - | 465 | WP_055065351.1 | hypothetical protein | - |
HPY08_RS15350 | 462838..463029 | - | 192 | WP_114717204.1 | hypothetical protein | - |
HPY08_RS15355 | 463216..463506 | - | 291 | WP_108336305.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
HPY08_RS15360 | 463496..463744 | - | 249 | WP_000213183.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 338606..521339 | 182733 | |
- | inside | Integron | - | - | 339770..520450 | 180680 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11682.58 Da Isoelectric Point: 4.8838
>T157984 WP_000229320.1 NZ_CP053809:458667-458969 [Vibrio cholerae]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDAKI
SILFVMRAERDLRRLMLTKQ
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDAKI
SILFVMRAERDLRRLMLTKQ
Download Length: 303 bp
>T157984 NZ_CP069528:3474970-3475227 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9647.15 Da Isoelectric Point: 7.3178
>AT157984 WP_000861987.1 NZ_CP053809:458422-458679 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
Download Length: 258 bp
>AT157984 NZ_CP069528:3475239-3475784 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCGGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCGGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | D7HHP0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1T4SLM9 |