Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 456870..457636 Replicon chromosome
Accession NZ_CP053809
Organism Vibrio cholerae strain SP7G

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag HPY08_RS15300 Protein ID WP_175242890.1
Coordinates 456870..457367 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag HPY08_RS15305 Protein ID WP_175242891.1
Coordinates 457364..457636 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY08_RS15270 452178..453833 + 1656 WP_061051387.1 DUF262 domain-containing HNH endonuclease family protein -
HPY08_RS15275 454028..454351 + 324 WP_080299109.1 DUF3709 domain-containing protein -
HPY08_RS15280 454784..455173 + 390 WP_000491261.1 VOC family protein -
HPY08_RS15285 455328..455825 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
HPY08_RS15290 455822..456094 - 273 WP_001915058.1 DUF1778 domain-containing protein -
HPY08_RS15295 456430..456666 + 237 WP_002051081.1 DUF645 family protein -
HPY08_RS15300 456870..457367 - 498 WP_175242890.1 GNAT family N-acetyltransferase Toxin
HPY08_RS15305 457364..457636 - 273 WP_175242891.1 DUF1778 domain-containing protein Antitoxin
HPY08_RS15310 457875..458213 + 339 WP_046127316.1 hypothetical protein -
HPY08_RS15315 458422..458679 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HPY08_RS15320 458667..458969 + 303 WP_000229320.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY08_RS15325 459130..459663 + 534 WP_000679868.1 GNAT family N-acetyltransferase -
HPY08_RS15330 459813..460268 + 456 WP_000432865.1 hypothetical protein -
HPY08_RS15335 460564..460746 + 183 WP_000923330.1 DUF645 family protein -
HPY08_RS15340 460952..461233 + 282 WP_000382665.1 hypothetical protein -
HPY08_RS15345 461306..461770 - 465 WP_055065351.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 338606..521339 182733
- inside Integron - - 339770..520450 180680


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18423.09 Da        Isoelectric Point: 8.7753

>T157983 WP_175242890.1 NZ_CP053809:c457367-456870 [Vibrio cholerae]
VMDTVLLDKVKHDRNRFNCGIGALNNYLKVMASQQAKKDNTRTFVLEDDNDSSHIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKYFYERYGFQAFQDAENKLFITIADV
RASLG

Download         Length: 498 bp

>T157983 NZ_CP069528:3437785-3438126 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACTGCGGTAGATGTCAAAGTAATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTCGCCTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9779.24 Da        Isoelectric Point: 8.6154

>AT157983 WP_175242891.1 NZ_CP053809:c457636-457364 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLTKAAAIAGMSSINSFVLSAAIEKAKQVIEREQALKLSQADAMLLMDALDRPTTQNSKLRA
ASERYESKAQ

Download         Length: 273 bp

>AT157983 NZ_CP069528:c3437790-3437714 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References