Detailed information of TA system TA157982

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /GNAT-DUF1778
• Location: 455328..456094
• Replicon: chromosome
• Accession: NZ_CP053809
• Organism: Vibrio cholerae strain SP7G

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9K2P7
• Locus tag: HPY08_RS15285
• Protein ID: WP_000982260.1
• Coordinates: 455328..455825 (-)
• Length: 166 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: HPY08_RS15290
• Protein ID: WP_001915058.1
• Coordinates: 455822..456094 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY08_RS15255	450667..451248	+	582	WP_175242889.1	nucleotidyltransferase family protein	-
HPY08_RS15260	451459..451713	+	255	WP_001223794.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
HPY08_RS15265	451706..451969	+	264	WP_000098715.1	Txe/YoeB family addiction module toxin	-
HPY08_RS15270	452178..453833	+	1656	WP_061051387.1	DUF262 domain-containing HNH endonuclease family protein	-
HPY08_RS15275	454028..454351	+	324	WP_080299109.1	DUF3709 domain-containing protein	-
HPY08_RS15280	454784..455173	+	390	WP_000491261.1	VOC family protein	-
HPY08_RS15285	455328..455825	-	498	WP_000982260.1	GNAT family N-acetyltransferase	Toxin
HPY08_RS15290	455822..456094	-	273	WP_001915058.1	DUF1778 domain-containing protein	Antitoxin
HPY08_RS15295	456430..456666	+	237	WP_002051081.1	DUF645 family protein	-
HPY08_RS15300	456870..457367	-	498	WP_175242890.1	GNAT family N-acetyltransferase	-
HPY08_RS15305	457364..457636	-	273	WP_175242891.1	DUF1778 domain-containing protein	-
HPY08_RS15310	457875..458213	+	339	WP_046127316.1	hypothetical protein	-
HPY08_RS15315	458422..458679	+	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
HPY08_RS15320	458667..458969	+	303	WP_000229320.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HPY08_RS15325	459130..459663	+	534	WP_000679868.1	GNAT family N-acetyltransferase	-
HPY08_RS15330	459813..460268	+	456	WP_000432865.1	hypothetical protein	-
HPY08_RS15335	460564..460746	+	183	WP_000923330.1	DUF645 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	338606..521339	182733
	-	inside	Integron	-	-	339770..520450	180680

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (86-152)

Antitoxin

• Vibrio phage ICP1, Orf50 (7-86)

Sequences

Toxin

Protein

• Length: 166 a.a.
• Molecular weight: 18527.18 Da
• Isoelectric Point: 8.7753

>T157982 WP_000982260.1 NZ_CP053809:c455825-455328 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Nucleotide

• Length: 498 bp

>T157982 NZ_CP069528:3358129-3358281 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9655.16 Da
• Isoelectric Point: 6.2988

>AT157982 WP_001915058.1 NZ_CP053809:c456094-455822 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVANAKLKL
ASERYESKTQ

Nucleotide

• Length: 273 bp

>AT157982 NZ_CP069528:c3358080-3358023 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: A0A0Q0KGB1