Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 425112..425677 Replicon chromosome
Accession NZ_CP053809
Organism Vibrio cholerae strain SP7G

Toxin (Protein)


Gene name relE Uniprot ID A0A271VGY0
Locus tag HPY08_RS15035 Protein ID WP_000869987.1
Coordinates 425390..425677 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID W9USL4
Locus tag HPY08_RS15030 Protein ID WP_000086650.1
Coordinates 425112..425393 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY08_RS14985 420222..420401 + 180 Protein_411 DUF645 family protein -
HPY08_RS14990 420803..420943 + 141 Protein_412 DUF645 family protein -
HPY08_RS14995 421141..421557 + 417 WP_000257355.1 hypothetical protein -
HPY08_RS15000 421856..422035 + 180 Protein_414 DUF645 family protein -
HPY08_RS15005 422230..422745 + 516 WP_175242876.1 hypothetical protein -
HPY08_RS15010 422727..422852 + 126 WP_114717185.1 DUF3265 domain-containing protein -
HPY08_RS15015 423043..423213 + 171 WP_162298991.1 DUF645 family protein -
HPY08_RS15020 423417..423881 + 465 WP_002033245.1 GNAT family N-acetyltransferase -
HPY08_RS15025 424037..424432 + 396 WP_057559337.1 DUF3465 domain-containing protein -
HPY08_RS15030 425112..425393 + 282 WP_000086650.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HPY08_RS15035 425390..425677 + 288 WP_000869987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY08_RS15040 425873..426196 + 324 WP_080299109.1 DUF3709 domain-containing protein -
HPY08_RS15045 426467..426859 + 393 WP_055052334.1 nuclear transport factor 2 family protein -
HPY08_RS15050 426999..427634 + 636 WP_000691786.1 DUF2807 domain-containing protein -
HPY08_RS15055 427945..428127 + 183 WP_000923156.1 DUF645 family protein -
HPY08_RS15060 428525..428655 + 131 Protein_426 DUF645 family protein -
HPY08_RS15065 429041..429382 - 342 WP_000070745.1 thiamine-binding protein -
HPY08_RS15070 429471..429581 + 111 Protein_428 DUF3265 domain-containing protein -
HPY08_RS15075 429608..430090 + 483 WP_000422941.1 GNAT family N-acetyltransferase -
HPY08_RS15080 430260..430631 + 372 WP_002045696.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 338606..521339 182733
- inside Integron - - 339770..520450 180680


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11031.76 Da        Isoelectric Point: 6.0710

>T157980 WP_000869987.1 NZ_CP053809:425390-425677 [Vibrio cholerae]
MKVVWSPLALQKLGDAAEFIAFDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV

Download         Length: 288 bp

>T157980 NZ_CP053809:425390-425677 [Vibrio cholerae]
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTGGGTGATGCCGCAGAGTTTATTGCTTTTGATAACCCATCAGC
TGCAGAAAAGTGGGTGAATGAAGTATTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCTG
AAATGCCTCATACGAACTACCGTGAAATAATTTTTGGTCATTACCGCATTATTTATAGTTTGAGCCACGAAATCCGCGTT
CTAACAGTTCGTAACTGTCGTCAATTGCTCACGGAACATGATGTGTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10347.90 Da        Isoelectric Point: 5.1548

>AT157980 WP_000086650.1 NZ_CP053809:425112-425393 [Vibrio cholerae]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGVSN
EDARSQVLGRIIK

Download         Length: 282 bp

>AT157980 NZ_CP053809:425112-425393 [Vibrio cholerae]
ATGAGCCGTATTCACCTTGATCAAGATATTCAGCCTTTGTCTGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAAACTCGTCGACCATTAGTTATTACACAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAATATGAAG
CAATGCAAGAGAAAATCGAATTACTTGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCAGGTTTGGGTGTATCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGACGCATCATCAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VGY0

Antitoxin

Source ID Structure
AlphaFold DB W9USL4

References