Detailed information of TA system TA157979

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DhiAT/-
• Location: 412628..413412
• Replicon: chromosome
• Accession: NZ_CP053809
• Organism: Vibrio cholerae strain SP7G

Toxin (Protein)

• Gene name: dhiT
• Uniprot ID: A0A086SLD6
• Locus tag: HPY08_RS14925
• Protein ID: WP_001114075.1
• Coordinates: 412628..412897 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: dhiA
• Uniprot ID: Q9KM84
• Locus tag: HPY08_RS14930
• Protein ID: WP_000921691.1
• Coordinates: 412891..413412 (+)
• Length: 174 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY08_RS14895	408025..408687	+	663	WP_000084910.1	Vat family streptogramin A O-acetyltransferase	-
HPY08_RS14900	409039..409134	+	96	WP_001907607.1	DUF645 family protein	-
HPY08_RS14905	409352..409729	-	378	WP_000734783.1	PEGA domain-containing protein	-
HPY08_RS14910	409970..410404	+	435	WP_000256033.1	GNAT family N-acetyltransferase	-
HPY08_RS14915	410556..411281	+	726	WP_095464285.1	hypothetical protein	-
HPY08_RS14920	411428..412423	+	996	WP_175242873.1	hypothetical protein	-
HPY08_RS14925	412628..412897	+	270	WP_001114075.1	DUF4160 domain-containing protein	Toxin
HPY08_RS14930	412891..413412	+	522	WP_000921691.1	DUF2442 domain-containing protein	Antitoxin
HPY08_RS14935	413706..413887	+	182	Protein_401	DUF645 family protein	-
HPY08_RS14940	414003..414197	+	195	WP_148533242.1	DUF3709 domain-containing protein	-
HPY08_RS14945	414191..414451	+	261	WP_175243018.1	DUF3709 domain-containing protein	-
HPY08_RS14950	414742..415839	+	1098	WP_045595979.1	hypothetical protein	-
HPY08_RS14955	416144..416314	+	171	WP_158118904.1	DUF645 family protein	-
HPY08_RS14960	416522..417160	+	639	WP_043990404.1	HD domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	338606..521339	182733
	-	inside	Integron	-	-	339770..520450	180680

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF4160 (9-74)

Antitoxin

• Protein of unknown function DUF2442 (4-59)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10310.94 Da
• Isoelectric Point: 6.6303

>T157979 WP_001114075.1 NZ_CP053809:412628-412897 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Nucleotide

• Length: 270 bp

>T157979 NZ_CP069528:2846958-2847176 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 174 a.a.
• Molecular weight: 19409.01 Da
• Isoelectric Point: 6.7342

>AT157979 WP_000921691.1 NZ_CP053809:412891-413412 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Nucleotide

• Length: 522 bp

>AT157979 NZ_CP069528:2846558-2846932 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• AlphaFold DB: A0A086SLD6

Antitoxin

• AlphaFold DB: Q9KM84