Detailed information of TA system TA157978

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 407342..407889
• Replicon: chromosome
• Accession: NZ_CP053809
• Organism: Vibrio cholerae strain SP7G

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HPY08_RS14890
• Protein ID: WP_000818171.1
• Coordinates: 407587..407889 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HPY08_RS14885
• Protein ID: WP_095490657.1
• Coordinates: 407342..407599 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY08_RS14845	402905..403441	+	537	WP_019281268.1	GNAT family N-acetyltransferase	-
HPY08_RS14850	403602..404138	+	537	WP_000831688.1	hypothetical protein	-
HPY08_RS14855	404281..404928	+	648	WP_175242869.1	hypothetical protein	-
HPY08_RS14860	404919..405035	+	117	WP_175242870.1	DUF3265 domain-containing protein	-
HPY08_RS14865	405195..405431	+	237	WP_162810550.1	DUF3709 domain-containing protein	-
HPY08_RS14870	405620..405700	+	81	Protein_388	acetyltransferase	-
HPY08_RS14875	405737..405973	-	237	WP_175242871.1	RNA-binding protein	-
HPY08_RS14880	406242..407150	+	909	WP_175242872.1	hypothetical protein	-
HPY08_RS14885	407342..407599	+	258	WP_095490657.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HPY08_RS14890	407587..407889	+	303	WP_000818171.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY08_RS14895	408025..408687	+	663	WP_000084910.1	Vat family streptogramin A O-acetyltransferase	-
HPY08_RS14900	409039..409134	+	96	WP_001907607.1	DUF645 family protein	-
HPY08_RS14905	409352..409729	-	378	WP_000734783.1	PEGA domain-containing protein	-
HPY08_RS14910	409970..410404	+	435	WP_000256033.1	GNAT family N-acetyltransferase	-
HPY08_RS14915	410556..411281	+	726	WP_095464285.1	hypothetical protein	-
HPY08_RS14920	411428..412423	+	996	WP_175242873.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	338606..521339	182733
	-	inside	Integron	-	-	339770..520450	180680

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11709.57 Da
• Isoelectric Point: 4.8838

>T157978 WP_000818171.1 NZ_CP053809:407587-407889 [Vibrio cholerae]
MAEIVWTEPALSDLNDIAEYIALENVVAAKQLVQTIFTKVERLADFPESGRIPPELEHLNYREVVVNPCRVFYKYDDANV
RILFVMRAERDLRRLMLTKQ

Nucleotide

• Length: 303 bp

>T157978 NZ_CP069528:c2819173-2818871 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9661.18 Da
• Isoelectric Point: 7.3180

>AT157978 WP_095490657.1 NZ_CP053809:407342-407599 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKERM
SKWLK

Nucleotide

• Length: 258 bp

>AT157978 NZ_CP069528:c2818835-2818494 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG