Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc(toxin) |
| Location | 401792..402363 | Replicon | chromosome |
| Accession | NZ_CP053809 | ||
| Organism | Vibrio cholerae strain SP7G | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | Q9KMA2 |
| Locus tag | HPY08_RS14835 | Protein ID | WP_000351248.1 |
| Coordinates | 401962..402363 (+) | Length | 134 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | - |
| Locus tag | HPY08_RS14830 | Protein ID | WP_175242868.1 |
| Coordinates | 401792..401962 (+) | Length | 57 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY08_RS14790 | 397201..397437 | + | 237 | WP_172776555.1 | DUF3709 domain-containing protein | - |
| HPY08_RS14795 | 397626..397718 | + | 93 | WP_175242865.1 | acetyltransferase | - |
| HPY08_RS14800 | 397715..398188 | + | 474 | WP_114808820.1 | hypothetical protein | - |
| HPY08_RS14805 | 398344..398739 | + | 396 | WP_175242866.1 | DUF3465 domain-containing protein | - |
| HPY08_RS14810 | 399354..400049 | + | 696 | WP_113592617.1 | hypothetical protein | - |
| HPY08_RS14815 | 400496..400690 | + | 195 | WP_175242867.1 | DUF3709 domain-containing protein | - |
| HPY08_RS14820 | 400684..400944 | + | 261 | WP_175243018.1 | DUF3709 domain-containing protein | - |
| HPY08_RS14825 | 401371..401553 | + | 183 | WP_001933694.1 | DUF645 family protein | - |
| HPY08_RS14830 | 401792..401962 | + | 171 | WP_175242868.1 | acetyltransferase | Antitoxin |
| HPY08_RS14835 | 401962..402363 | + | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| HPY08_RS14840 | 402333..402476 | + | 144 | WP_175243019.1 | DUF3265 domain-containing protein | - |
| HPY08_RS14845 | 402905..403441 | + | 537 | WP_019281268.1 | GNAT family N-acetyltransferase | - |
| HPY08_RS14850 | 403602..404138 | + | 537 | WP_000831688.1 | hypothetical protein | - |
| HPY08_RS14855 | 404281..404928 | + | 648 | WP_175242869.1 | hypothetical protein | - |
| HPY08_RS14860 | 404919..405035 | + | 117 | WP_175242870.1 | DUF3265 domain-containing protein | - |
| HPY08_RS14865 | 405195..405431 | + | 237 | WP_162810550.1 | DUF3709 domain-containing protein | - |
| HPY08_RS14870 | 405620..405700 | + | 81 | Protein_388 | acetyltransferase | - |
| HPY08_RS14875 | 405737..405973 | - | 237 | WP_175242871.1 | RNA-binding protein | - |
| HPY08_RS14880 | 406242..407150 | + | 909 | WP_175242872.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 338606..521339 | 182733 | |
| - | inside | Integron | - | - | 339770..520450 | 180680 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 134 a.a. Molecular weight: 14608.71 Da Isoelectric Point: 4.0128
>T157977 WP_000351248.1 NZ_CP053809:401962-402363 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL
Download Length: 402 bp
>T157977 NZ_CP069528:2513277-2513657 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATCGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCTGGGCAGGCATCCGGAGGAGGCGAAACAATGA
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATCGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCTGGGCAGGCATCCGGAGGAGGCGAAACAATGA
Antitoxin
Download Length: 57 a.a. Molecular weight: 6288.29 Da Isoelectric Point: 10.4058
>AT157977 WP_175242868.1 NZ_CP053809:401792-401962 [Vibrio cholerae]
MNRKVEAYGVDAVERPEIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM
MNRKVEAYGVDAVERPEIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM
Download Length: 171 bp
>AT157977 NZ_CP069528:2512853-2513230 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCATCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAATCACCGTATAA
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCATCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAATCACCGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|