Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 346534..347081 Replicon chromosome
Accession NZ_CP053809
Organism Vibrio cholerae strain SP7G

Toxin (Protein)


Gene name relE Uniprot ID A0A151JFV0
Locus tag HPY08_RS14360 Protein ID WP_061900969.1
Coordinates 346779..347081 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag HPY08_RS14355 Protein ID WP_000861987.1
Coordinates 346534..346791 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY08_RS14305 341579..342004 + 426 WP_032473260.1 hypothetical protein -
HPY08_RS14310 342696..343529 + 834 WP_175242835.1 hypothetical protein -
HPY08_RS14315 343526..343675 + 150 WP_175243014.1 DUF3265 domain-containing protein -
HPY08_RS14320 343688..343999 + 312 WP_000623749.1 hypothetical protein -
HPY08_RS14325 344188..344586 + 399 WP_095488424.1 hypothetical protein -
HPY08_RS14330 344550..344693 + 144 WP_175243015.1 DUF3265 domain-containing protein -
HPY08_RS14335 344721..344990 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
HPY08_RS14340 344983..345261 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
HPY08_RS14345 345624..345797 + 174 WP_114716423.1 DUF645 family protein -
HPY08_RS14350 346060..346233 - 174 WP_175242836.1 hypothetical protein -
HPY08_RS14355 346534..346791 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HPY08_RS14360 346779..347081 + 303 WP_061900969.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY08_RS14365 347091..347207 + 117 Protein_287 DUF3265 domain-containing protein -
HPY08_RS14370 347241..347729 + 489 WP_175242837.1 hypothetical protein -
HPY08_RS14375 347864..348328 + 465 WP_175242838.1 N-acetyltransferase -
HPY08_RS14380 348397..348486 + 90 WP_175242839.1 acetyltransferase -
HPY08_RS14385 348486..348776 + 291 WP_175242840.1 hypothetical protein -
HPY08_RS14390 348849..349313 - 465 WP_175242841.1 hypothetical protein -
HPY08_RS14395 349814..349984 + 171 WP_162298991.1 DUF645 family protein -
HPY08_RS14400 350182..350631 + 450 WP_057556343.1 GyrI-like domain-containing protein -
HPY08_RS14405 350618..350746 + 129 WP_080390558.1 DUF3265 domain-containing protein -
HPY08_RS14410 350881..351117 + 237 WP_001065132.1 hypothetical protein -
HPY08_RS14415 351310..351813 + 504 WP_175242842.1 DinB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 338606..521339 182733
- inside Integron - - 339770..520450 180680


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11768.68 Da        Isoelectric Point: 4.9166

>T157975 WP_061900969.1 NZ_CP053809:346779-347081 [Vibrio cholerae]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDEKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T157975 NZ_CP069528:c1704082-1703804 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT157975 WP_000861987.1 NZ_CP053809:346534-346791 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT157975 NZ_CP069528:c1703804-1703520 [Escherichia coli]
ATGAAAATGGTCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCAGAA
AAAACAGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JFV0

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References