Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 709811..710339 | Replicon | chromosome |
| Accession | NZ_CP053807 | ||
| Organism | Vibrio cholerae strain SP6G | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | H9L4R3 |
| Locus tag | HPY07_RS17050 | Protein ID | WP_000221352.1 |
| Coordinates | 710049..710339 (+) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | H9L4T4 |
| Locus tag | HPY07_RS17045 | Protein ID | WP_000213183.1 |
| Coordinates | 709811..710059 (+) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY07_RS16995 | 704832..705155 | - | 324 | WP_080299109.1 | DUF3709 domain-containing protein | - |
| HPY07_RS17000 | 705350..705739 | - | 390 | WP_175242351.1 | VOC family protein | - |
| HPY07_RS17005 | 705803..706654 | - | 852 | WP_175242301.1 | IS3 family transposase | - |
| HPY07_RS17010 | 706738..706959 | - | 222 | Protein_728 | transposase | - |
| HPY07_RS17015 | 707246..707488 | + | 243 | WP_001961623.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY07_RS17020 | 707507..707824 | + | 318 | WP_001180243.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY07_RS17025 | 707960..708390 | - | 431 | Protein_731 | nucleotidyltransferase family protein | - |
| HPY07_RS17030 | 708643..709080 | - | 438 | WP_114818872.1 | NUDIX pyrophosphatase | - |
| HPY07_RS17035 | 709078..709155 | - | 78 | Protein_733 | GNAT family N-acetyltransferase | - |
| HPY07_RS17040 | 709279..709389 | - | 111 | Protein_734 | DUF645 family protein | - |
| HPY07_RS17045 | 709811..710059 | + | 249 | WP_000213183.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| HPY07_RS17050 | 710049..710339 | + | 291 | WP_000221352.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HPY07_RS17055 | 710388..710948 | - | 561 | WP_114716203.1 | GNAT family N-acetyltransferase | - |
| HPY07_RS17060 | 711274..711435 | - | 162 | WP_175242352.1 | hypothetical protein | - |
| HPY07_RS17065 | 711554..712558 | - | 1005 | WP_000964932.1 | LD-carboxypeptidase | - |
| HPY07_RS17070 | 712844..713167 | - | 324 | WP_080479241.1 | DUF3709 domain-containing protein | - |
| HPY07_RS17075 | 713349..713804 | - | 456 | WP_114717223.1 | hypothetical protein | - |
| HPY07_RS17080 | 713811..713882 | - | 72 | Protein_742 | acetyltransferase | - |
| HPY07_RS17085 | 713998..714174 | - | 177 | WP_161780499.1 | DUF645 family protein | - |
| HPY07_RS17090 | 714476..715189 | - | 714 | WP_175242353.1 | Fic family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 703084..723599 | 20515 | |
| - | inside | Integron | - | - | 703084..719384 | 16300 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11247.23 Da Isoelectric Point: 10.4678
>T157972 WP_000221352.1 NZ_CP053807:710049-710339 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD
Download Length: 291 bp
>T157972 NZ_CP069528:1031964-1032218 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 8937.28 Da Isoelectric Point: 4.1079
>AT157972 WP_000213183.1 NZ_CP053807:709811-710059 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL
Download Length: 249 bp
>AT157972 NZ_CP069528:1031716-1031967 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | H9L4R3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A366A3W8 |