Detailed information of TA system TA157969

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-Phd
• Location: 465186..465764
• Replicon: chromosome
• Accession: NZ_CP053807
• Organism: Vibrio cholerae strain SP6G

Toxin (Protein)

• Gene name: parE
• Uniprot ID: O68848
• Locus tag: HPY07_RS15960
• Protein ID: WP_001180243.1
• Coordinates: 465186..465503 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: HPY07_RS15965
• Protein ID: WP_001961623.1
• Coordinates: 465522..465764 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY07_RS15920	460397..460642	-	246	WP_001260801.1	type II toxin-antitoxin system CcdA family antitoxin	-
HPY07_RS15925	460845..461363	+	519	WP_057556356.1	GNAT family N-acetyltransferase	-
HPY07_RS15930	461521..462321	+	801	WP_175242316.1	PhzF family phenazine biosynthesis protein	-
HPY07_RS15935	462552..462977	+	426	WP_047691697.1	hypothetical protein	-
HPY07_RS15940	463171..463407	-	237	WP_000792784.1	ST-I family heat-stable enterotoxin	-
HPY07_RS15945	463803..463981	+	179	Protein_516	DUF645 family protein	-
HPY07_RS15950	464284..464520	+	237	WP_001065132.1	hypothetical protein	-
HPY07_RS15955	464838..464991	+	154	Protein_518	DUF645 family protein	-
HPY07_RS15960	465186..465503	-	318	WP_001180243.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY07_RS15965	465522..465764	-	243	WP_001961623.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HPY07_RS15970	466034..466270	-	237	WP_000772125.1	RNA-binding protein	-
HPY07_RS15975	466524..467450	+	927	WP_076025812.1	PD-(D/E)XK nuclease superfamily protein	-
HPY07_RS15980	467746..467928	+	183	WP_175242317.1	DUF645 family protein	-
HPY07_RS15985	468280..468462	+	183	WP_114763558.1	DUF645 family protein	-
HPY07_RS15990	468669..469370	+	702	WP_001175917.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	309110..469370	160260
	-	inside	Integron	-	-	309781..469370	159589
	-	flank	IS/Tn	-	-	469573..470961	1388

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12158.97 Da
• Isoelectric Point: 9.7495

>T157969 WP_001180243.1 NZ_CP053807:c465503-465186 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Nucleotide

• Length: 318 bp

>T157969 NZ_CP069528:116726-117133 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8931.22 Da
• Isoelectric Point: 5.6630

>AT157969 WP_001961623.1 NZ_CP053807:c465764-465522 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDGGKTVDGATFLNTL

Nucleotide

• Length: 243 bp

>AT157969 NZ_CP069528:116479-116745 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATTCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A0K9UJR8