Detailed information of TA system TA157968

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-Phd
• Location: 439679..440257
• Replicon: chromosome
• Accession: NZ_CP053807
• Organism: Vibrio cholerae strain SP6G

Toxin (Protein)

• Gene name: parE
• Uniprot ID: O68848
• Locus tag: HPY07_RS15735
• Protein ID: WP_001180243.1
• Coordinates: 439679..439996 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: HPY07_RS15740
• Protein ID: WP_001961623.1
• Coordinates: 440015..440257 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY07_RS15700	435446..435556	+	111	Protein_467	DUF645 family protein	-
HPY07_RS15705	436082..436192	+	111	WP_080478889.1	DUF3265 domain-containing protein	-
HPY07_RS15710	436227..436649	+	423	WP_017045852.1	hypothetical protein	-
HPY07_RS15715	436898..437134	+	237	WP_042988412.1	hypothetical protein	-
HPY07_RS15720	437297..437917	+	621	WP_175242309.1	hypothetical protein	-
HPY07_RS15725	438074..438610	+	537	WP_175242310.1	GNAT family N-acetyltransferase	-
HPY07_RS15730	438765..439532	+	768	WP_175242311.1	hypothetical protein	-
HPY07_RS15735	439679..439996	-	318	WP_001180243.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY07_RS15740	440015..440257	-	243	WP_001961623.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HPY07_RS15745	440596..440832	+	237	WP_175242312.1	hypothetical protein	-
HPY07_RS15750	441037..441927	+	891	WP_148514094.1	hypothetical protein	-
HPY07_RS15755	441939..442049	+	111	WP_080368089.1	DUF3265 domain-containing protein	-
HPY07_RS15760	442663..442896	+	234	WP_010319470.1	DUF3709 domain-containing protein	-
HPY07_RS15765	443322..443503	+	182	Protein_480	DUF645 family protein	-
HPY07_RS15770	443704..444348	+	645	WP_175242313.1	hypothetical protein	-
HPY07_RS15775	444335..444463	+	129	WP_114708974.1	DUF3265 domain-containing protein	-
HPY07_RS15780	444501..445139	+	639	WP_069730854.1	HD domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	309110..469370	160260
	-	inside	Integron	-	-	309781..469370	159589

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12158.97 Da
• Isoelectric Point: 9.7495

>T157968 WP_001180243.1 NZ_CP053807:c439996-439679 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Nucleotide

• Length: 318 bp

>T157968 NZ_CP069523:44222-44383 [Escherichia coli]
ATGAAACTACCGGGAAACGCCCTTATCTGGTGCGTATTAATCGTGTGCTGCACGTTGTTGATATTCACACTCCTGACCCG
GAATCGCCTGTGCGAAGTCCGGCTGAAGGACGGATACAGGGAAGTTACGGCAACAATGGCTTACGAATCCGGCGGTAAGT
AG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8931.22 Da
• Isoelectric Point: 5.6630

>AT157968 WP_001961623.1 NZ_CP053807:c440257-440015 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDGGKTVDGATFLNTL

Nucleotide

• Length: 243 bp

>AT157968 NZ_CP069523:43970-44170 [Escherichia coli]
CCCGTGAACTGGCTGAACGACCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGGATATGAGCTATGATGTG
CCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAGGCAGAAAGCCCCGT
AGTTAATTTTTCATTAACCCACGAGGCCCCCTGTATGTCTA

Structures

Toxin

• AlphaFold DB: A0A0K9UJR8