Detailed information of TA system TA157967

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DhiAT/-
• Location: 420208..420992
• Replicon: chromosome
• Accession: NZ_CP053807
• Organism: Vibrio cholerae strain SP6G

Toxin (Protein)

• Gene name: dhiT
• Uniprot ID: A0A086SLD6
• Locus tag: HPY07_RS15590
• Protein ID: WP_001114075.1
• Coordinates: 420208..420477 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: dhiA
• Uniprot ID: -
• Locus tag: HPY07_RS15595
• Protein ID: WP_071180725.1
• Coordinates: 420471..420992 (+)
• Length: 174 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY07_RS15545	415280..415855	+	576	WP_055028419.1	NAD(P)H-dependent oxidoreductase	-
HPY07_RS15550	415912..416019	+	108	WP_175242304.1	acetyltransferase	-
HPY07_RS15555	416922..417191	-	270	WP_000277238.1	type II toxin-antitoxin system YafQ family toxin	-
HPY07_RS15560	417184..417462	-	279	WP_001258569.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
HPY07_RS15565	417816..417998	+	183	WP_000923156.1	DUF645 family protein	-
HPY07_RS15570	418214..418495	+	282	WP_001100052.1	hypothetical protein	-
HPY07_RS15575	418701..419237	+	537	WP_071180368.1	GNAT family N-acetyltransferase	-
HPY07_RS15580	419437..419718	+	282	WP_175242305.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
HPY07_RS15585	419715..420002	+	288	WP_000869999.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HPY07_RS15590	420208..420477	+	270	WP_001114075.1	DUF4160 domain-containing protein	Toxin
HPY07_RS15595	420471..420992	+	522	WP_071180725.1	DUF2442 domain-containing protein	Antitoxin
HPY07_RS15600	421148..422029	+	882	WP_001959558.1	NAD(P)-dependent oxidoreductase	-
HPY07_RS15605	422324..422506	+	183	WP_076008572.1	DUF645 family protein	-
HPY07_RS15610	422703..423179	+	477	WP_001047180.1	GNAT family N-acetyltransferase	-
HPY07_RS15615	423327..424037	+	711	WP_175242306.1	bacteriophage abortive infection AbiH family protein	-
HPY07_RS15620	424367..424774	+	408	WP_032473179.1	hypothetical protein	-
HPY07_RS15625	425079..425250	+	172	Protein_452	DUF645 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	309110..469370	160260
	-	inside	Integron	-	-	309781..469370	159589

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF4160 (9-74)

Antitoxin

• Protein of unknown function DUF2442 (4-59)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10310.94 Da
• Isoelectric Point: 6.6303

>T157967 WP_001114075.1 NZ_CP053807:420208-420477 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Nucleotide

• Length: 270 bp

>T157967 NZ_CP069523:17405-17554 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin

Protein

• Length: 174 a.a.
• Molecular weight: 19368.95 Da
• Isoelectric Point: 6.8848

>AT157967 WP_071180725.1 NZ_CP053807:420471-420992 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGHADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELSAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Nucleotide

• Length: 522 bp

>AT157967 NZ_CP069523:c17357-17301 [Escherichia coli]
GTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Structures

Toxin

• AlphaFold DB: A0A086SLD6