Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 419437..420002 | Replicon | chromosome |
| Accession | NZ_CP053807 | ||
| Organism | Vibrio cholerae strain SP6G | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D7HCW8 |
| Locus tag | HPY07_RS15585 | Protein ID | WP_000869999.1 |
| Coordinates | 419715..420002 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | HPY07_RS15580 | Protein ID | WP_175242305.1 |
| Coordinates | 419437..419718 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY07_RS15535 | 414931..415134 | + | 204 | WP_039553825.1 | hypothetical protein | - |
| HPY07_RS15540 | 415137..415253 | + | 117 | WP_080726405.1 | DUF3265 domain-containing protein | - |
| HPY07_RS15545 | 415280..415855 | + | 576 | WP_055028419.1 | NAD(P)H-dependent oxidoreductase | - |
| HPY07_RS15550 | 415912..416019 | + | 108 | WP_175242304.1 | acetyltransferase | - |
| HPY07_RS15555 | 416922..417191 | - | 270 | WP_000277238.1 | type II toxin-antitoxin system YafQ family toxin | - |
| HPY07_RS15560 | 417184..417462 | - | 279 | WP_001258569.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| HPY07_RS15565 | 417816..417998 | + | 183 | WP_000923156.1 | DUF645 family protein | - |
| HPY07_RS15570 | 418214..418495 | + | 282 | WP_001100052.1 | hypothetical protein | - |
| HPY07_RS15575 | 418701..419237 | + | 537 | WP_071180368.1 | GNAT family N-acetyltransferase | - |
| HPY07_RS15580 | 419437..419718 | + | 282 | WP_175242305.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| HPY07_RS15585 | 419715..420002 | + | 288 | WP_000869999.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HPY07_RS15590 | 420208..420477 | + | 270 | WP_001114075.1 | DUF4160 domain-containing protein | - |
| HPY07_RS15595 | 420471..420992 | + | 522 | WP_071180725.1 | DUF2442 domain-containing protein | - |
| HPY07_RS15600 | 421148..422029 | + | 882 | WP_001959558.1 | NAD(P)-dependent oxidoreductase | - |
| HPY07_RS15605 | 422324..422506 | + | 183 | WP_076008572.1 | DUF645 family protein | - |
| HPY07_RS15610 | 422703..423179 | + | 477 | WP_001047180.1 | GNAT family N-acetyltransferase | - |
| HPY07_RS15615 | 423327..424037 | + | 711 | WP_175242306.1 | bacteriophage abortive infection AbiH family protein | - |
| HPY07_RS15620 | 424367..424774 | + | 408 | WP_032473179.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 309110..469370 | 160260 | |
| - | inside | Integron | - | - | 309781..469370 | 159589 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10997.74 Da Isoelectric Point: 6.0710
>T157966 WP_000869999.1 NZ_CP053807:419715-420002 [Vibrio cholerae]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV
Download Length: 288 bp
>T157966 NZ_CP069522:c5055064-5054753 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATAAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATAAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10347.90 Da Isoelectric Point: 5.1548
>AT157966 WP_175242305.1 NZ_CP053807:419437-419718 [Vibrio cholerae]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQVAAGLGISN
EDARSQVLGRIIK
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQVAAGLGISN
EDARSQVLGRIIK
Download Length: 282 bp
>AT157966 NZ_CP069522:c5054752-5054462 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|