157965

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 416922..417462 Replicon chromosome
Accession NZ_CP053807
Organism Vibrio cholerae strain SP6G

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag HPY07_RS15555 Protein ID WP_000277238.1
Coordinates 416922..417191 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag HPY07_RS15560 Protein ID WP_001258569.1
Coordinates 417184..417462 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY07_RS15520 412076..412399 + 324 WP_080476600.1 DUF3709 domain-containing protein -
HPY07_RS15525 412713..413036 + 324 WP_080476600.1 DUF3709 domain-containing protein -
HPY07_RS15530 413316..414752 + 1437 WP_175242303.1 hypothetical protein -
HPY07_RS15535 414931..415134 + 204 WP_039553825.1 hypothetical protein -
HPY07_RS15540 415137..415253 + 117 WP_080726405.1 DUF3265 domain-containing protein -
HPY07_RS15545 415280..415855 + 576 WP_055028419.1 NAD(P)H-dependent oxidoreductase -
HPY07_RS15550 415912..416019 + 108 WP_175242304.1 acetyltransferase -
HPY07_RS15555 416922..417191 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
HPY07_RS15560 417184..417462 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HPY07_RS15565 417816..417998 + 183 WP_000923156.1 DUF645 family protein -
HPY07_RS15570 418214..418495 + 282 WP_001100052.1 hypothetical protein -
HPY07_RS15575 418701..419237 + 537 WP_071180368.1 GNAT family N-acetyltransferase -
HPY07_RS15580 419437..419718 + 282 WP_175242305.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HPY07_RS15585 419715..420002 + 288 WP_000869999.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY07_RS15590 420208..420477 + 270 WP_001114075.1 DUF4160 domain-containing protein -
HPY07_RS15595 420471..420992 + 522 WP_071180725.1 DUF2442 domain-containing protein -
HPY07_RS15600 421148..422029 + 882 WP_001959558.1 NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 309110..469370 160260
- inside Integron - - 309781..469370 159589


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T157965 WP_000277238.1 NZ_CP053807:c417191-416922 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T157965 NZ_CP069522:c4863874-4863488 [Escherichia coli]
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGTGTCCCCCACGATCCGTCTTGCGTCTTGAATTCTGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCTGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATCTCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT157965 WP_001258569.1 NZ_CP053807:c417462-417184 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT157965 NZ_CP069522:c4864476-4863904 [Escherichia coli]
ATGTTTTGCGAAGAAAAAGTAGCTCAAATGGCTGCATACCTACTTCTTAAGAGAGGTGGGCGCATGGCATATCTGAAATT
GATGAAGCTGCTCTATCTGTCTAACCGCCAGTCGATTTTGAAGCATGGCAGGATGATCGGCGAAGATAGCCTTTACTCTA
TGAAATTTGGACCAGTCATGTCGAATACGCTGAACTTGATTCGCGGTAAGGCTGAAGGCATTGGTGACTACTGGTACAAC
TTGATAGAGACGAACGGGCATAATGTATCGTTGCGTTCAGATCCGAGGGAAATGGATGCAGACGAGGTCTTTGATGAATT
GAGTCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCGGTATGGGCATATGAACCGATTTGATCTCGCAAATATGA
CGCATTTAGAAAGCGTTTGTCCAGAGTGGCACGATCCTGGCAACTCTCGTAAGCCTATAGACCTGAAAGAAATGCTGATC
AGTGAGGGTAAAAGCGAGGATGAGGCTAATCGCATAATTGGCAAAATGGAAGAATCTCAGAAACTTAAGGAATTTTCTTT
GCAATTATCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References