Detailed information of TA system TA157964

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-phd/RelE(toxin)
• Location: 401158..401647
• Replicon: chromosome
• Accession: NZ_CP053807
• Organism: Vibrio cholerae strain SP6G

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HPY07_RS15420
• Protein ID: WP_000818171.1
• Coordinates: 401158..401460 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: HPY07_RS15425
• Protein ID: WP_080481658.1
• Coordinates: 401534..401647 (+)
• Length: 38 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY07_RS15390	396681..397892	-	1212	WP_175242300.1	hypothetical protein	-
HPY07_RS15395	398800..399123	+	324	WP_080476600.1	DUF3709 domain-containing protein	-
HPY07_RS15400	399461..400045	+	585	WP_033933188.1	hypothetical protein	-
HPY07_RS15405	400175..400336	+	162	Protein_408	DUF3709 domain-containing protein	-
HPY07_RS15410	400372..400524	+	153	WP_175242275.1	DUF3709 domain-containing protein	-
HPY07_RS15415	400913..401170	+	258	WP_095490657.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
HPY07_RS15420	401158..401460	+	303	WP_000818171.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY07_RS15425	401534..401647	+	114	WP_080481658.1	acetyltransferase	Antitoxin
HPY07_RS15430	401596..401877	+	282	WP_001894429.1	DUF1289 domain-containing protein	-
HPY07_RS15435	402177..402398	+	222	Protein_414	transposase	-
HPY07_RS15440	402482..403333	+	852	WP_175242301.1	IS3 family transposase	-
HPY07_RS15445	403398..403880	+	483	WP_032482862.1	hypothetical protein	-
HPY07_RS15450	404024..404365	+	342	WP_055030598.1	hypothetical protein	-
HPY07_RS15455	404517..405044	+	528	WP_175242302.1	hypothetical protein	-
HPY07_RS15460	405140..405745	+	606	WP_175242423.1	suppressor of fused domain protein	-
HPY07_RS15465	405750..405860	+	111	WP_080100071.1	DUF3265 domain-containing protein	-
HPY07_RS15470	405889..406395	+	507	WP_000403019.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	309110..469370	160260
	-	inside	Integron	-	-	309781..469370	159589

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11709.57 Da
• Isoelectric Point: 4.8838

>T157964 WP_000818171.1 NZ_CP053807:401158-401460 [Vibrio cholerae]
MAEIVWTEPALSDLNDIAEYIALENVVAAKQLVQTIFTKVERLADFPESGRIPPELEHLNYREVVVNPCRVFYKYDDANV
RILFVMRAERDLRRLMLTKQ

Nucleotide

• Length: 303 bp

>T157964 NZ_CP069522:c4710703-4710530 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 38 a.a.
• Molecular weight: 4239.13 Da
• Isoelectric Point: 9.8095

>AT157964 WP_080481658.1 NZ_CP053807:401534-401647 [Vibrio cholerae]
VVSVVVFEFSVMRCQPLRRALCVFLKNFHSSALIIQT

Nucleotide

• Length: 114 bp

>AT157964 NZ_CP069522:c4711027-4710731 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG