Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-Phd |
| Location | 400913..401460 | Replicon | chromosome |
| Accession | NZ_CP053807 | ||
| Organism | Vibrio cholerae strain SP6G | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | HPY07_RS15420 | Protein ID | WP_000818171.1 |
| Coordinates | 401158..401460 (+) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | HPY07_RS15415 | Protein ID | WP_095490657.1 |
| Coordinates | 400913..401170 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY07_RS15385 | 395924..396502 | + | 579 | WP_000864968.1 | hypothetical protein | - |
| HPY07_RS15390 | 396681..397892 | - | 1212 | WP_175242300.1 | hypothetical protein | - |
| HPY07_RS15395 | 398800..399123 | + | 324 | WP_080476600.1 | DUF3709 domain-containing protein | - |
| HPY07_RS15400 | 399461..400045 | + | 585 | WP_033933188.1 | hypothetical protein | - |
| HPY07_RS15405 | 400175..400336 | + | 162 | Protein_408 | DUF3709 domain-containing protein | - |
| HPY07_RS15410 | 400372..400524 | + | 153 | WP_175242275.1 | DUF3709 domain-containing protein | - |
| HPY07_RS15415 | 400913..401170 | + | 258 | WP_095490657.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| HPY07_RS15420 | 401158..401460 | + | 303 | WP_000818171.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HPY07_RS15425 | 401534..401647 | + | 114 | WP_080481658.1 | acetyltransferase | - |
| HPY07_RS15430 | 401596..401877 | + | 282 | WP_001894429.1 | DUF1289 domain-containing protein | - |
| HPY07_RS15435 | 402177..402398 | + | 222 | Protein_414 | transposase | - |
| HPY07_RS15440 | 402482..403333 | + | 852 | WP_175242301.1 | IS3 family transposase | - |
| HPY07_RS15445 | 403398..403880 | + | 483 | WP_032482862.1 | hypothetical protein | - |
| HPY07_RS15450 | 404024..404365 | + | 342 | WP_055030598.1 | hypothetical protein | - |
| HPY07_RS15455 | 404517..405044 | + | 528 | WP_175242302.1 | hypothetical protein | - |
| HPY07_RS15460 | 405140..405745 | + | 606 | WP_175242423.1 | suppressor of fused domain protein | - |
| HPY07_RS15465 | 405750..405860 | + | 111 | WP_080100071.1 | DUF3265 domain-containing protein | - |
| HPY07_RS15470 | 405889..406395 | + | 507 | WP_000403019.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 309110..469370 | 160260 | |
| - | inside | Integron | - | - | 309781..469370 | 159589 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11709.57 Da Isoelectric Point: 4.8838
>T157963 WP_000818171.1 NZ_CP053807:401158-401460 [Vibrio cholerae]
MAEIVWTEPALSDLNDIAEYIALENVVAAKQLVQTIFTKVERLADFPESGRIPPELEHLNYREVVVNPCRVFYKYDDANV
RILFVMRAERDLRRLMLTKQ
MAEIVWTEPALSDLNDIAEYIALENVVAAKQLVQTIFTKVERLADFPESGRIPPELEHLNYREVVVNPCRVFYKYDDANV
RILFVMRAERDLRRLMLTKQ
Download Length: 303 bp
>T157963 NZ_CP069522:4698929-4699306 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCATCTCCCGTAACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCTCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCCCCGGTTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCGGGGTAAGCATCCGGAGGCGAAACAATGA
ATGAACACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCATCTCCCGTAACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCTCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCCCCGGTTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCGGGGTAAGCATCCGGAGGCGAAACAATGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9661.18 Da Isoelectric Point: 7.3180
>AT157963 WP_095490657.1 NZ_CP053807:400913-401170 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKERM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKERM
SKWLK
Download Length: 258 bp
>AT157963 NZ_CP069522:4698471-4698839 [Escherichia coli]
GTGTCAGACACGCACCATGAGACAAATTATCCCGACGACTATAACAACCGCCCCTGGTGGGGGCTGCCCTGCACCATAAC
ACCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGTATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGACTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACACGCACCATGAGACAAATTATCCCGACGACTATAACAACCGCCCCTGGTGGGGGCTGCCCTGCACCATAAC
ACCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGTATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGACTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|